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17.09.2024

Multiplex Microscopy Assay for Assessment of Therapeutic and Serum Antibodies against Emerging Pathogens

Authors Sartingen N, Stürmer V, Kaltenböck M, Müller TG, Schnitzler P, Kreshuk A, Kräusslich HG, Merle U, Mücksch F, Müller B, Pape C, Laketa V Journal Viruses Citation Viruses 2024, 16(9), 1473. Abstract The emergence of novel pathogens, exemplified recently by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights
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17.09.2024

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

Authors Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, Brose N, Taschenberger H, Krueger-Burg D Journal Communications Biology Citation Commun Biol. 2024 Sep 17;7(1):1157. Abstract Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all
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17.09.2024

Salon Debate “Animal experiments in science”

What are the arguments for and against animal experiments in science? How are they currently regulated? What animal-free methods are available? And how can these be used effectively in research? The ethical issues surrounding the topic of animal testing are complex. How does science meet these challenges?   Journalist and
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13.09.2024

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

Authors Naas J, Nies G, Li H, Stoldt S, Schmitzer B, Jakobs S, Munk A Journal Communications Biology Citation Commun Biol 7, 1139 (2024). Abstract With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate
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12.09.2024

The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathy

Authors Chopra A, Xylaki M, Yin F, Castro-Hernández R, Merghani M, Grande V, Mollenhauer B, Fischer A, Outeiro TF Journal BioRxiv Citation bioRxiv 2024.09.12.612649. Abstract N6-methyladenosine (m6A) is the most abundant and conserved transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A in the development of
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The first and last authors of the study in front of the heart research building of the University Medical Center Göttingen (from left to right): Dominik Hubricht, medical student; Dr Fleur Mason, postdoctoral researcher; Vanessa Möller, medical student; Dr Funsho Fakuade, postdoctoral researcher and Prof Dr Niels Voigt, Professor of Molecular Pharmacology at the Institute of Pharmacology and Toxicology. Photo: Julia Szikszay

10.09.2024

Defective ‘shock absorber’ in heart muscle cells contributes to the development of atrial fibrillation

Impaired calcium buffering in heart muscle cells promotes the progression and perpetuation of atrial fibrillation. This was discovered by researchers from the Heart Center of the University Medical Center Göttingen (UMG) and the German Centre for Cardiovascular Research (DZHK). The findings offer potential starting points for new therapies. The results
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10.09.2024

Animal experiments in science

Salon Debate on September 17, 2024 at Forum Wissen   „Animal experiments in science“ is the topic of an event on Tuesday, September 17, 2024, at 6.30 p.m. in the Forum Wissen at the University of Göttingen. It is part of the “Salon Debates” series, which addresses current issues from
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The first and last authors of the study in front of the heart research building of the University Medical Center Göttingen (from left to right): Dominik Hubricht, medical student; Dr Fleur Mason, postdoctoral researcher; Vanessa Möller, medical student; Dr Funsho Fakuade, postdoctoral researcher and Prof Dr Niels Voigt, Professor of Molecular Pharmacology at the Institute of Pharmacology and Toxicology. Photo: Julia Szikszay

10.09.2024

Defective ‘shock absorber’ in heart muscle cells contributes to the development of atrial fibrillation

Impaired calcium buffering in heart muscle cells promotes the progression and perpetuation of atrial fibrillation. This was discovered by researchers from the Heart Center of the University Medical Center Göttingen (UMG) and the German Centre for Cardiovascular Research (DZHK). The findings offer potential starting points for new therapies. The results
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10.09.2024

KRASG12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

Authors Tapia Contreras C, Falke JD, Seifert DM, Schneider C, Krauß L, Fang X, Müller D, Demirdizen E, Spitzner M, De Oliveira T, Schneeweis C, Gaedcke J, Kaulfuß S, Mirzakhani K, Wollnik B, Conrads K, Beißbarth T, Salinas G, Hügel J, Beyer N, Rheinländer S, Sax U, Wirth M, Conradi
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09.09.2024

Rational approximation of golden angles: Accelerated reconstructions for radial MRI

Authors Scholand N, Schaten P, Graf C, Mackner D, Holme HCM, Blumenthal M, Mao A, Assländer J, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2024 Sep 9. Abstract Purpose: To develop a generic radial sampling scheme that combines the advantages of golden ratio sampling with simplicity
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