September

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27.09.2024

Measuring 3-dimensional dynamics of membrane in living cell with metal-induced energy transfer imaging/spectroscopy

Authors Chen T, Gallea JI, Karedla N, Wang D, Enderlein J Journal BioRxiv Citation bioRxiv 2024.09.27.614973. Abstract The dynamics of cellular membranes are crucial for many essential cellular processes. Despite various methods available to study membrane dynamics, simultaneously measuring membrane diffusion and fluctuations within living cell membranes remains challenging. In
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25.09.2024

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

Authors Bergner CG, van der Meer F, Franz J, Vakrakou A, Würfel T, Nessler S, Schäfer L, Nau-Gietz C, Winkler A, Lagumersindez-Denis N, Wrzos C, Damkou IA, Sergiou C, Schultz V, Knauer C, Metz I, Bahn E, Rodriguez EG, Merkler D, Simons M, Stadelmann C Journal Brain Citation Brain. 2024
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25.09.2024

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Authors Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstteter M, Fernandez Busnadiego R, Zimprich A, Outeiro TF Journal MedRxiv Citation medRxiv 2024.09.23.24313864. Abstract Background: Parkinson’s
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Fadhel El May at work at the University Medical Center Goettingen. Courtesy: J Moser / MBExC

24.09.2024

About listening and belonging

Fadhel El May is researching a new generation of cochlear implants which could revolutionize hearing with implants. But Hertha Sponer College member El May is not only a scientist, he is also affected himself: he has been profoundly deaf since birth.   Link to Science Notes interview (article in German)
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24.09.2024

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts

Authors Ruiz-Orera J, Miller DC, Greiner J, Genehr C, Grammatikaki A, Blachut S, Mbebi J, Patone G, Myronova A, Adami E, Dewani N, Liang N, Hummel O, Muecke MB, Hildebrandt TB, Fritsch G, Schrade L, Zimmermann WH, Kondova I, Diecke S, van Heesch S, Hübner N Journal Nature Cardiovascular Research
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23.09.2024

MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Authors Bharti A, Ajinkya K, Andrea MM, Ramos-Gomes F, Bohnenberger H, Ströbel P, Alves F, Klein O Journal npj Imaging Citation npj Imaging 2, 35 (2024). Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, accentuated by its heterogeneity and complex tumour microenvironment (TME). The role of
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19.09.2024

Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT

Authors Engeholm M, Roske JJ, Oberbeckmann E, Dienemann C, Lidschreiber M, Cramer P, Farnung L Journal Molecular Cell Citation Mol Cell. 2024 Sep 19;84(18):3423-3437.e8. Abstract To maintain the nucleosome organization of transcribed genes, ATP-dependent chromatin remodelers collaborate with histone chaperones. Here, we show that at the 5′ ends of yeast
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18.09.2024

The plasma miRNAome in ADNI: signatures to aid the detection of at-risk individuals

Authors Krüger MD, Pena-Centeno T, Lui S, Park T, Kaurani L, Pradhan R, Huang YN, Risacher S, Burkhardt S, Schütz AL, Wang Y, Shaw LM, Brodsky A, DeStefano AL, Lin H, Schroeder R, Krunic A, Hempel N, Sananbenesi F, Blusztajn JK, Saykin AJ, Delalle I, Nho K, Fischer A Journal
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Prof. Dr. André Fischer, research group leader at DZNE’s Göttingen site and professor of epigenetics of neurodegenerative diseases at the University Medical Center Göttingen (UMG)

18.09.2024

Blood Testing for so-called MicroRNAs Can Detect Dementia

Dementia due to Alzheimer’s disease and its preliminary stage can be detected by measuring so-called microRNAs in blood. Researchers from DZNE in Göttingen, together with US experts from Boston University and the Indiana University School of Medicine, report on this in the scientific journal Alzheimer’s & Dementia: The Journal of
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18.09.2024

Plasma miRNAs across the Alzheimer’s disease continuum: Relationship to central biomarkers

Authors Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K; Alzheimer’s Disease Neuroimaging Initiative Journal
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