February

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16.02.2024

RNA helicase IGHMBP2 regulates THO complex to ensure cellular mRNA homeostasis

Authors Prusty AB, Hirmer A, Sierra-Delgado JA, Huber H, Guenther UP, Schlosser A, Dybkov O, Yildirim E, Urlaub H, Meyer KC, Jablonka S, Erhard F, Fischer U   Journal Cell Reports   Citation Cell Rep. 2024 Feb 16;43(2):113802.   Abstract RNA helicases constitute a large protein family implicated in cellular
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13.02.2024

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)

Authors Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, Andreas LB, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2024 Feb 13;15(1):1297. Abstract Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the
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09.02.2024

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction

Authors Gotthardt M, Lehnart SE   Journal Cardiovascular Research   Citation Cardiovasc Res. 2024 Feb 9:cvae030.   Abstract No abstract available.   DOI 10.1093/cvr/cvae030   Pubmed Link
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08.02.2024

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

Authors Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S   Journal Nature Structural & Molecular Biology   Citation Nat Struct Mol Biol (2024).   Abstract Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system
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08.02.2024

Model-Based Reconstruction for Joint Estimation of T1, R∗2 and B0 Field Maps Using Single-Shot Inversion-Recovery Multi-Echo Radial FLASH

Authors Wang X, Scholand N, Tan Z, Mackner D, Telezki V, Blumenthal M, Schaten P, Uecker M Journal Arxiv Citation arXiv:2402.05366. Abstract Purpose: To develop a model-based nonlinear reconstruction for simultaneous water-specific T1, R∗2, B0 field and/or fat fraction (FF) mapping using single-shot inversion-recovery (IR) multi-echo radial FLASH. Methods: The
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08.02.2024

Recordings of Public Lecture Series “Herz und Hirn gemeinsam im Fokus” online

„Herz und Hirn gemeinsam im Fokus“ (Heart and Brain in focus together) is the title of the public lecture series of the University of Göttingen and the Lower Saxony Academy of Sciences and Humanities in Göttingen in the winter semester 2023/2024. In the series, MBExC scientists gave comprehensive insights into
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07.02.2024

Characterizing ATP processing by the AAA+ protein p97 at the atomic level

Authors Shein M, Hitzenberger M, Cheng T, Rout S, Leitl K, Sato Y, Zacharias M, Sakata E, Schuetz A Journal Nature Chemistry Citation Nat. Chem. (2024). Abstract The human enzyme p97 regulates various cellular pathways by unfolding hundreds of protein substrates in an ATP-dependent manner, making it an essential component
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01.02.2024

A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria

Authors Höglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE Journal The Lancet. Neurology Citation Lancet Neurol. 2024 Feb;23(2):191-204. Erratum in: Lancet Neurol. 2024 Mar;23(3):e7. Abstract With the hope that disease-modifying treatments could target the molecular basis of Parkinson’s disease, even
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01.02.2024

Limit distributions and sensitivity analysis for empirical entropic optimal transport on countable spaces

Authors Hundrieser S, Klatt M, Munk A Journal The Annals of Applied Probability Citation Ann. Appl. Probab. 34(1B): 1403-1468. Abstract For probability measures on countable spaces we derive distributional limits for empirical entropic optimal transport quantities. More precisely, we show that the empirical optimal transport plan weakly converges to a
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Prof. Dr. Tobias Moser, Director of the Institute for Auditory Neuroscience, University Medical Center Göttingen and spokesperson of the CRC 1690. Photo: mbexc/spförtner

01.02.2024

New gene therapy for children born deaf in clinical trials

To date, hearing impairment can only be treated with medical devices such as hearing aids or cochlear implants. Gene therapy could offer an alternative in certain cases in the future. Building on pioneering work by researchers at the University Medical Center Göttingen (UMG), children suffering from a hearing impairment due
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