2023

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09.09.2023

An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex

Authors Enz LS, Winkler A, Wrzos C, Dasen B, Nessler S, Stadelmann C, Schaeren-Wiemers N Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2023 Sep 9;24(18):13893. Abstract Modeling chronic cortical demyelination allows the study of long-lasting pathological changes observed in multiple sclerosis such as failure of remyelination,
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MBExC member Tiago Outeiro, Director at the Dep. of Experimental Neurodegeneration, UMG, interviewed by Hertha Sponer College member Svilen Georgiev, Dep. of Neuro- and Sensory Physiology, UMG. Source: "Neuroscience and Beyond", Youtube.

08.09.2023

New “Neuroscience and Beyond” Episode with Tiago Outeiro

In the new episode of the Podcast “Neuroscience and Beyond”, MBExC member Tiago Outeiro, Director of the Department of Experimental Neurodegeneration, University Medical Center Göttingen (UMG), talks about “Protein Aggregation and Parkinson’s Disease”. The focus of this interview is on Parkinson’s disease, its potential causes, underlying problematic protein structures, associated
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07.09.2023

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development

Authors Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A, Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Díaz I Pedrosa N, Rapedius M, Döring Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Brügmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann
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06.09.2023

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses

Authors Karagulyan N, Moser T Journal Frontiers in Molecular Neuroscience – Molecular Signalling and Pathways Citation Front Mol Neurosci. 2023 Sep 6;16:1248941. Abstract Neural sound encoding in the mammalian cochlea faces the challenge of representing audible sound pressures that vary over six orders of magnitude. The cochlea meets this demand
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Prof. Dr. Hauke Hillen, University Medical Center Göttingen and Max Planck Institute for Multidisciplinary Sciences. Photo: Irene Böttcher-Gajewski, MPI-NAT.

Prof. Dr. Hauke Hillen, University Medical Center Göttingen and Max Planck Institute for Multidisciplinary Sciences. Photo: Irene Böttcher-Gajewski, MPI-NAT.

05.09.2023

ERC Starting Grant for Hauke Hillen

The European Research Council (ERC) is funding the work of MBExC member Prof. Dr. Hauke Hillen, Institute of Cell Biochemistry, University Medical Center Göttingen and Max Planck Institute for Multidisciplinary Sciences, with an ERC Starting Grant of 1.5 million euros for a period of five years.   This highly endowed,
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05.09.2023

Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

Authors Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB Journal Nature Communications Citation Nat Commun. 2023 Sep 5;14(1):5395. Abstract The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility and fertilization via HCO3−-stimulated cAMP synthesis. A complex
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03.09.2023

Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).

Authors Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Sep 3. Abstract The receptor for advanced glycation end products (RAGE) is a protein of the
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30.08.2023

N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

Authors Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein A, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M Journal iScience Citation iScience. 2023 Aug 30;26(10):107786. Abstract N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing
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30.08.2023

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease

Authors Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(17) Abstract Parkinson’s disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites
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25.08.2023

En route to sound coding strategy for optical cochlear implants

Authors Khurana L, Harczos T, Moser T, Jablonski L Journal iScience Citation iScience (2023). Abstract In 2019, disabling hearing loss affected 430 million people worldwide and will reach over 700 million by 2050. Severe-to-complete sensorineural hearing loss is often treated by electrical cochlear implants (eCIs) bypassing dysfunctional or lost hair
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