2023

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05.12.2023

Evaluation of MR-safe bioptomes for MR-guided endomyocardial biopsy in minipigs: a potential radiation-free clinical approach

Authors Svetlove A, Ritter CO, Dullin C, Schmid M, Schauer S, Uihlein J, Uecker M, Mietsch M, Stadelmann C, Lotz J, Unterberg-Buchwald C Journal European Radiology Experimental Citation Eur Radiol Exp. 2023 Dec 5;7(1):76. Abstract Background: Diagnostic accuracy of endomyocardial biopsy could improve if clinically safe magnetic resonance (MR)-compatible bioptomes
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05.12.2023

The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro

Authors Wicke D, Neumann P, Gößringer M, Chernev A, Davydov S, Poehlein A, Daniel R, Urlaub H, Hartmann RK, Ficner R, Stülke J Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 5:gkad1171. Abstract Even though Bacillus subtilis is one of the most studied organisms, no function has been
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Prof. Dr. Dr. Tobias Brügmann, University Medical Center Göttingen Photo: MBExC

05.12.2023

Detecting side effects of new drugs on the heart more efficiently

Scientists at the University Medical Center and the University of Göttingen have developed a new approach to keep intact heart tissue for about two weeks in culture for more efficient cardiotoxicity screening of new active substances and therapeutic approaches. The advantage: this method is already effective in a very early
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Prof. Dr. Dr. Tobias Brügmann, University Medical Center Göttingen Photo: MBExC

05.12.2023

Detecting side effects of new drugs on the heart more efficiently

Scientists at the University Medical Center and the University of Göttingen have developed a novel method to predict the side effects of new drugs and therapeutic approaches on the heart more efficiently. The advantage: this method is already effective in a very early test phase, even before preclinical screening in
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30.11.2023

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

Authors Altas B, Rhee HJ, Ju A, Solís HC, Karaca S, Winchenbach J, Kaplan-Arabaci O, Schwark M, Ambrozkiewicz MC, Lee C, Spieth L, Wieser GL, Chaugule VK, Majoul I, Hassan MA, Goel R, Wojcik SM, Koganezawa N, Hanamura K, Rotin D, Pichler A, Mitkovski M, de Hoz L, Poulopoulos A,
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29.11.2023

Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity

Authors Lin SJ, Vona B, Lau T, Huang K, Zaki MS, Aldeen HS, Karimiani EG, Rocca C, Noureldeen MM, Saad AK, Petree C, Bartolomaeus T, Abou Jamra R, Zifarelli G, Gotkhindikar A, Wentzensen IM, Liao M, Cork EE, Varshney P, Hashemi N, Mohammadi MH, Rad A, Neira J, Toosi MB,
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29.11.2023

Most discriminative stimuli for functional cell type identification

Authors Burg MF, Zenkel T, Vystrčilová M, Oesterle J, Höfling L, Willeke KF, Lause J, Müller S, Fahey PG, Ding Z, Restivo K, Sridhar S, Gollisch T, Berens P, Tolias AS, Euler T, Bethge M, Ecker AS Journal ArXiv Citation arXiv:2401.05342. Abstract Identifying cell types and understanding their functional properties
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29.11.2023

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Authors Jaime Tobón LM, Moser T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. Abstract In our hearing organ, sound is encoded at ribbon synapses formed by inner hair cells (IHCs) and spiral
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28.11.2023

Boosting of neural circuit chaos at the onset of collective oscillations

Authors Palmigiano A, Engelken R, Wolf F Journal eLife Citation eLife 12:RP90378. Abstract Neuronal spiking activity in cortical circuits is often temporally structured by collective rhythms. Rhythmic activity has been hypothesized to regulate temporal coding and to mediate the flexible routing of information flow across the cortex. Spiking neuronal circuits,
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28.11.2023

Structure and dynamics of human cardiac fibroblast nanotubes

Authors Schmid-Herbstritt SC, Stief G, Greiner J, Felekary A, Madl J, Zeidler V, Heer J, Iaconianni P, Koch M, Kollmar K, Walz C, Nubling S, Kok T, Pronto JR, Kutschka I, Voigt N, Morgan G, Dienert J, Brox T, Briquez P, Peyronnet R, Rohrbach A, Kohl P, Rog-Zielinska EA Journal
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