Prof. Dr. Dr. Tobias Brügmann, University Medical Center Göttingen Photo: MBExC

Detecting side effects of new drugs on the heart more efficiently

Scientists at the University Medical Center and the University of Göttingen have developed a novel method to predict the side effects of new drugs and therapeutic approaches on the heart more efficiently. The advantage: this method is already effective in a very early test phase, even before preclinical screening in the living organism. The results were published in the renowned journal Cardiovascular Research.
A team led by Prof. Dr. Tobias Brügmann, research group leader at the Institute of Cardiovascular Physiology at the University Medical Center Göttingen (UMG), in cooperation with Prof. Dr. Tim Salditt, Director of the Institute of X-ray Physics at the University of Göttingen, both members of the Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC), have now developed a way to keep fresh slices of intact heart tissue in culture for several days while demonstrably preserving vitality and functionality.
Link to the press release article