2023

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24.05.2023

The long-loop recycling (LLR) of synaptic components as a question of economics

Authors Georgiev SV, Rizzoli SO Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2023 May 24;126:103862. Abstract The pre- and post-synaptic compartments contain a variety of molecules that are known to recycle between the plasma membrane and intracellular organelles. The recycling steps have been amply described in functional terms,
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24.05.2023

Flotillin-associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

Authors Haro-Moreno JM, López-Pérez M, Alekseev A, Podoliak E, Kovalev K, Gordeliy V, Stepanauskas R, Rodriguez-Valera F Journal mSystems Citation mSystems. 2023 May 24:e0000823. Abstract Microbial rhodopsins are found more than once in a single genome (paralogs) often have different functions. We screened a large dataset of open ocean single-amplified
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Scientific Image by Alexey Chizhik Third Institute of Physics University of Goettingen
23.05.2023

EMBO Workshop

The EMBO Workshop “Mechanisms of membrane fusion” will take place from 18 until 22 September at the Max Planck Institute for Multidisciplinary Sciences, Faßberg Campus in Göttingen. Fusion of biological membranes is fundamental to all living organisms and includes a wide range of processes such as infection by enveloped viruses,
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23.05.2023

UMG meets Diversity

Diversity Day is a nationwide event taking place this year on 23 May. The aim is to raise awareness, stimulate discussion and develop concrete measures to promote diversity and equal opportunities. The University Medical Center Göttingen invites everyone to listen to the first two episodes of the podcast series “UMG
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22.05.2023

Modulating Secondary Structure Motifs through Photo-labile Peptide Staples

Authors Lāce I, Bazzi S, Uranga J, Schirmacher A, Diederichsen U, Mata RA, Simeth NA Journal ChemBioChem Citation Chembiochem. 2023 May 22:e202300270. Abstract Peptide-protein interactions (PPIs) are facilitated by the well-defined three-dimensional structure of bioactive peptides, interesting compounds for the development of new therapeutic agents. Their secondary structure and thus
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18.05.2023

A Measure of the Complexity of Neural Representations based on Partial Information Decomposition

Authors Ehrlich DA, Schneider AC, Priesemann V, Wibral M, Makkeh A Journal Transactions on Machine Learning Research Citation Transactions on Machine Learning Research (2023). Abstract In neural networks, task-relevant information is represented jointly by groups of neurons. However, the specific way in which this mutual information about the classification label
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11.05.2023

Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography

Authors Reichmann J, Verleden SE, Kühnel M, Kamp JC, Werlein C, Neubert L, Müller JH, Bui TQ, Ackermann M, Jonigk D, Salditt T Journal Physics in Medicine and Biology Citation Phys Med Biol. 2023 May 11. Abstract As the central organ of the respiratory system, the human lung is responsible
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10.05.2023

Structural basis of catalytic activation in human splicing

Authors Schmitzová J, Cretu C, Dienemann C, Urlaub H, Pena V Journal Nature Citation Nature. 2023 May 10. Abstract Pre-mRNA splicing follows a pathway driven by ATP-dependent RNA helicases. A crucial event of the splicing pathway is the catalytic activation, which takes place at the transition between the activated Bact
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09.05.2023

Protein transport along the presequence pathway

Authors Makki A, Rehling P Journal Biological Chemistry Citation Biol Chem. 2023 May 9. Abstract Most mitochondrial proteins are nuclear-encoded and imported by the protein import machinery based on specific targeting signals. The proteins that carry an amino-terminal targeting signal (presequence) are imported via the presequence import pathway that involves
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08.05.2023

Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson’s Disease”

Authors Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ Journal Movement Disorders Citation Mov Disord. 2023 May 8. Abstract Background: More than 200 years
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