2023

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09.08.2023

Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice

Authors Placido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(16), 12607. Abstract Huntington’s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without
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08.08.2023

Modulation of translational decoding by m6A modification of mRNA

Authors Jain S, Koziej L, Poulis P, Kaczmarczyk I, Gaik M, Rawski M, Ranjan N, Glatt S, Rodnina MV Journal Nature Communications Citation Nat Commun. 2023 Aug 8;14(1):4784. Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding
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07.08.2023

Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis

Authors Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2023 Aug 7:166835. Abstract Different SOD1 proteoforms are implicated## in both familial and sporadic cases of Amyotrophic Lateral Sclerosis
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07.08.2023

Structural conservation of antibiotic interaction with ribosomes

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are
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Prof. Nadja Simeth-Crespi, MBExC member and leader of the Molecular Labeling Chemistry group at the Institute for Organic and Biomolecular Chemistry, University of Göttingen. Photo: MBExC / Swen Pförtner.

04.08.2023

ESP Young Investigator Award 2023 for Nadja Simeth-Crespi

MBExC junior fellow Nadja Simeth-Crespi receives ESP Young Investigator Award As recently announced by the European Society for Photobiology (ESP) on X, former Twitter, MBExC Junior Research Group leader and PI Nadja A. Simeth-Crespi, Institute of Organic and Biomolecular Chemistry, University of Göttingen, receives the 2023 ESP Young Investigator Award.
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01.08.2023

Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies

Authors Chopra A, Outeiro TF Journal Brain Citation Brain. 2023 Aug 1:awad260. Abstract Parkinson’s disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called ‘Lewy bodies’ and ‘Lewy neurites’. Together with dementia with Lewy
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28.07.2023

Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson’s disease

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a
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Information processing in the Deep Neural Network: the content of the image (the handwritten number 3) is read. The intermediate layers take in the information one after the other. In the process, it is distributed to the artificial neurons. In the final stage, the output layer outputs a number, which should match the input value. The artificial neurons specialise: one neuron becomes active when, for example, a three is shown, another neuron becomes active when a nine is shown. Figure: David Ehrlich, CIDBN, University of Göttingen

27.07.2023

Looking deep into the Network

Göttingen research team explores information processing in Deep Neural Networks Artificial neural networks are everywhere in research and technology, as well as in everyday technologies such as speech recognition. Despite this, it is still unclear to researchers what is exactly going on deep down in these networks. To find out,
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Patrick Cramer received the Bavarian Maximiliansorden. Photos: Bavarian state goverment

26.07.2023

Patrick Cramer received Bavarian “Maximiliansorden”

Patrick Cramer, president of the Max Planck Society and MBExC member, received the Bavarian “Maximiliansorden” for Science and Art on 26 July. The “Maximiliansorden” is awarded every two years by the Minister President in recognition of outstanding achievements in the fields of science and art and represents a particularly high
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20.07.2023

Force generation in human blood platelets by filamentous actomyosin structures

Authors Zelená A, Blumberg J, Probst D, Gerasimaitė R, Lukinavicius G, Schwarz US, Köster S Journal Biophysical Journal Citation Biophys J. 2023 Jul 19:S0006-3495(23)00461-7. Abstract Blood platelets are central elements of the blood clotting response after wounding. Upon vessel damage, they bind to the surrounding matrix and contract the forming
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