2022

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08.09.2022

The murine male reproductive organ at a glance: Three-dimensional insights and virtual histology using label-free light sheet microcopy

Authors Pinkert-Leetsch D, Rost JU, Schmiedeknecht MUH, Stadelmann C, Alves F, Missbach-Guentner J Journal Andrology Citation Andrology. 2022 Sep 8. Abstract Background: The unique anatomy of the male reproductive organ reflects its complex function from sperm maturation to their storage for months until emission. Since light microscopy in two dimensions
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08.09.2022

Ectosomes and exosomes modulate neuronal spontaneous activity

Authors Brás IC, Khani MH, Riedel D, Parfentev I, Gerhardt E, van Riesen C, Urlaub H, Gollisch T, Outeiro TF Journal Journal of Proteomics Citation J Proteomics. 2022 Sep 8:104721. Abstract Extracellular vesicles (EVs) are important mediators in intercellular communication. However, understanding the biological origin and functional effects of EVs
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06.09.2022

Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis

Authors Brandenburg S, Otto L, Schönberger HL, Jacob CF, Paulke NJ, Beuthner BE, Topci R, Kohl T, Neuenroth L, Kutschka I, Urlaub H, Kück F, Leha A, Friede T, Seidler T, Jacobshagen C, Toischer K, Puls M, Hasenfuß G, Lenz C, Lehnart SE Journal Journal of Molecular and Cellular Cardiology
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06.09.2022

Tackling the Dynamic Range Problem of Hearing: Diverse Hair Cell Synapses Enable Broad Neural Sound Intensity Coding

Authors Jaime Tobón LM, Moser T Journal Cell Reports Citation Cell Rep, 2022. under review. Abstract Synaptic heterogeneity can expand the encoding capacity of individual neurons or sensory cells. The afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea exhibit marked heterogeneity in structure
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06.09.2022

Aneuploidy in mammalian oocytes and the impact of maternal ageing

Authors Charalambous C, Webster A, Schuh M Journal Nature Reviews Molecular Cell Biology Citation Nat Rev Mol Cell Biol. 2022 Sep 6. Abstract During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo. However, human eggs frequently contain an incorrect
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This image shows a mouse mammary tumor. It was taken with a so-called two-photon microscope. Tumor cells are visible in green, collagen fibers in red, and fat deposits in magenta. The Short-Wave-Infrared Microscope (SWIM) that is built as part of the FAIR CHARM project will enable to visualize such structures at unprecedented tissue depth. © Fernanda Ramos Gomes / MPI-NAT

05.09.2022

Millions in funding for groundbreaking microscopy developments

The research project FAIR CHARM aims to apply findings from basic scientific research to clinical applications with the aid of high-resolution, real-time imaging. The EU is funding the project with six million euro. The range of expertise is covered by an interdisciplinary consortium of six international universities and research institutions
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02.09.2022

5th Göttingen Heart Day (5. Göttinger Herztag)

On September 3, the 5th Göttingen Heart Day of the Heart Center Göttingen (University Medical Center Göttingen) and the Heart & Vascular Center at Neu Bethlehem Hospital, Göttingen, will take place under the patronage of Göttingen’s mayor Petra Broistedt, in the Alte Mensa in Göttingen. MBExC member Gerd Hasenfuß, Director
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Interacting Particles Image by J. Naas (CIBIV), A. Munk, H. Li, G. Nies, B. Schmitzer (University of Göttingen)

02.09.2022

“MultiMatch” – “Colocalization Project” at Ars Electronica 2022 in Linz

Supported by the MBExC, Julia Naas (Center for Integrative Bioinformatics Vienna, CIBIV) in collaboration with MBExC member Axel Munk, MBExC Application Specialist Housen Li, Giacomo Nies and Berhard Schmitzer (all Institute for Mathematical Stochastics, University of Göttingen), have designed a 3D virtual journey to represent the optimal transport between protein
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Handing over the funding to the UMG (from left): Dr. Gabriele Andretta (President of the State Parliament of Lower Saxony), Daniela Behrens (Minister of Social Affairs of Lower Saxony) to Dr. Dagmar Weise (Medical Director of the Child Protection Outpatient Clinic), Prof. Dr. Jutta Gärtner (Director of the Clinic for Paediatrics and Adolescent Medicine), Prof. Wolfgang Brück (Spokesperson of the UMG Board of Directors). Photo: umg/spförtner

02.09.2022

New UMG child protection outpatient clinic receives funding

Daniela Behrens, Lower Saxony’s Minister for Social Affairs, Health and Equality, visited the University Medical Center Göttingen (UMG). For the newly established child protection outpatient clinic in the Department of Paediatrics and Adolescent Medicine at the UMG, led by MBExC member Jutta Gärtner, the Minister handed over a funding of
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01.09.2022

DNA-PAINT MINFLUX nanoscopy

Authors Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S Journal Nature Methods Citation Nat Methods (2022). Abstract MINimal fluorescence photon FLUXes (MINFLUX) nanoscopy, providing photon-efficient fluorophore localizations, has brought about three-dimensional resolution at nanometer scales. However, by using an intrinsic on–off switching
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