2022

Home >> 2022 >> Page 6
Feature image not available
01.10.2022

A Water-Soluble Manganese(II) Octanediaoate/Phenanthroline Complex Acts as an Antioxidant and Attenuates Alpha-Synuclein Toxicity

Authors DQueiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. Abstract
Learn More
27.09.2022

Experience the senses

„Tag der Sinne“ („Day of Senses“) on Oktober 8, 2022 at the Forum Wissen in Göttingen Hearing, seeing, smelling, tasting and touching –  with our senses, we perceive our environment every day. We experience the chirping of birds, the taste of our favourite ice cream or the beauty of a
Learn More

Start of the new ECTU station at UMG (from left): Prof. Dr. Frank Behrens (Division Head Clinical Studies at Fraunhofer ITMP), Prof. Dr. Martin Weber (Head ECTU at Fraunhofer ITMP, Translational Neuroinflammation and Automated Microscopy TNM), Prof. Dr. Stefan Jakobs (Site Manager Fraunhofer ITMP, Translational Neuroinflammation and Automated Microscopy TNM), Prof. Wolfgang Brück (UMG Board Speaker), Dr. Sabine Johannsen (State Secretary at MWK), Prof. Dr. Dr. Gerd Geißlinger (Head of Fraunhofer ITMP). Photo: umg/spförtner

23.09.2022

New Early Clinical Trial Unit (ECTU) at UMG and ITMP

The University Medical Center Göttingen (UMG) and the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP opened an Early Clinical Trial Unit (ECTU) for early clinical phase I studies on Thursday, September 15, 2022. The focus is on the first clinical testing of compounds for the treatment of largely intractable
Learn More
Feature image not available
21.09.2022

Distribution of Distances based Object Matching: Asymptotic Inference

Authors Weitkamp CA, Proksch K, Tameling C, Munk A Journal Journal of the American Statistical Association Citation J Am Stat Assoc. 1-32. 2022. Abstract In this paper, we aim to provide a statistical theory for object matching based on a lower bound of the Gromov-Wasserstein distance related to the distribution
Learn More
Feature image not available
20.09.2022

New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain

Authors Weninger G, Lehnart SE Journal Journal of Cellular Signaling Citation J Cell Signal. 2022;3(4):171-178. Abstract Junctophilin-2 (JP2) is a key structural protein of junctional membrane complexes (JMCs) that stabilize contacts between the sarcoplasmic reticulum and transverse tubules required for excitation-contraction (EC) coupling in cardiomyocytes. Under pathophysiological conditions, the intracellular
Learn More
Feature image not available
15.09.2022

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes

Authors Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, Becker N, Majumder R, Clauß S, Fertig N, Voigt N. Journal Communications Biology Citation Commun Biol 2022 Sep 15;5(1):969. Abstract Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer from low-throughput and require considerable experimenter expertise. Automated
Learn More
Feature image not available
15.09.2022

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane

Authors Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F Journal Biomedicines Citation Biomedicines 2022, 10(9), 2294. Abstract The flavoprotein kynurenine 3-monooxygenase (KMO) is localised to the outer mitochondrial membrane and catalyses the synthesis of
Learn More
Feature image not available
14.09.2022

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

Authors Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2022 Sep 14;13(1):5385. Abstract Aggregation of amyloidogenic proteins is a characteristic of
Learn More
Feature image not available
14.09.2022

Skeletal Class III Malocclusion Is Associated with ADAMTS2 Variants and Reduced Expression in a Familial Case

Authors Yao S, Zhou X, Vona B, Fan L, Zhang C, Li D, Yuan H, Du Y, Ma L, Pan Y Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2022 Sep 14;23(18):10673. Abstract Skeletal Class III malocclusion with maxillary deficiency is a severe maxillofacial disease with unclear
Learn More
Feature image not available
09.09.2022

Interdomain Dynamics via Paramagnetic NMR on the Highly Flexible Complex Calmodulin/Munc13-1

Authors Karschin N, Becker S, Griesinger C Journal Journal of the American Chemical Society Citation J Am Chem Soc. 2022 Sep 9. Abstract Paramagnetic NMR constraints are very useful to study protein interdomain motion, but their interpretation is not always straightforward. On the example of the particularly flexible complex Calmodulin/Munc13-1,
Learn More
X
EN DE
X
X