2022

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22.07.2022

Unique technology platform at the MBExC Cluster of Excellence combines cellular electrophysiology and optogenetics

New technology platform combines high-throughput recordings of cellular electrophysiology of isolated cardiomyocytes and neurons and their optical stimulation with light. Electrical activity is one of the most important common features of the heart and the brain. The goal of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to
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22.07.2022

Unique technology platform at the MBExC Cluster of Excellence combines cellular electrophysiology and optogenetics

New technology platform combines high-throughput recordings of cellular electrophysiology of isolated cardiomyocytes and neurons and their optical stimulation with light. Electrical activity is one of the most important common features of the heart and the brain. The goal of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to
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21.07.2022

Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues

Authors Santos GL, DeGrave AN, Rehman A, Al Disi S, Xhaxho K, Schröder H, Bao G, Meyer T, Tiburcy M, Dworatzek E, Zimmermann WH, Lutz S Journal Biomaterials Advances Citation Biomater Adv. 2022 Jul 21:213041. Abstract Tissue engineering with human cardiac fibroblasts (CF) allows identifying novel mechanisms and anti-fibrotic drugs
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Simulation of an optical Cochlea Implant. Image: Lakshay Khurana and Daniel Keppeler, UMG.

18.07.2022

Restoring Hearing With Beams of Light

There’s a popular misconception that cochlear implants restore natural hearing. In fact, these marvels of engineering give people a new kind of “electric hearing” that they must learn how to use. The scientists led by Tobias Moser, MBExC spokesperson, recognize that today’s cochlear implants run up against hard limits of
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16.07.2022

Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease

Authors Seefelder M, Klein FAC, Landwehrmeyer B, Fernández-Busnadiego R, Kochanek S Journal Journal of Huntington’s Disease Citation J Huntingtons Dis. 2022 Jul 16. Abstract Since the discovery of the mutation causing Huntington’s disease (HD) in 1993, it has been debated whether an expanded polyglutamine (polyQ) stretch affects the properties of
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3D-MINFLUX data of the protein bassoon in the synapses of rod photoreceptors prepared using Heat Assisted Rapid Dehydration (HARD). (Source: abberior Instruments)

15.07.2022

Molecular map of the synapse

Scientists at the Institute for Auditory Neuroscience, UMG, the Max Planck Institute for Multidisciplinary Sciences and the abberior Instruments GmbH apply high-resolution 3D-MINFLUX technology for precise 3D representation of the molecular organization in the active zone of rod photoreceptor cells. Published in Science Advances. (umg/mbexc) For the processing of sensory
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3D-MINFLUX data of the protein bassoon in the synapses of rod photoreceptors prepared using Heat Assisted Rapid Dehydration (HARD). (Source: abberior Instruments)

15.07.2022

Molecular map of the synapse

Scientists at the Institute for Auditory Neuroscience, UMG, the Max Planck Institute for Multidisciplinary Sciences and the abberior Instruments GmbH apply high-resolution 3D-MINFLUX technology for precise 3D representation of the molecular organization in the active zone of rod photoreceptor cells. Published in Science Advances. Link to the press release of
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14.07.2022

Is there an unmet medical need for improved hearing restoration?

Authors Wolf BJ, Kusch K, Hunniford V, Vona B, Kühler R, Keppeler D, Strenzke N, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2022 Jul 14:e15798. Abstract Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for
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13.07.2022

Structure of a backtracked hexasomal intermediate of nucleosome transcription

Authors Farnung L, Ochmann M, Garg G, Vos SM, Cramer P Journal Molecular Cell Citation Mol Cell. 2022 Jul 13:S1097-2765(22)00610-4. Abstract During gene transcription, RNA polymerase II (RNA Pol II) passes nucleosomes with the help of various elongation factors. Here, we show that RNA Pol II achieves efficient nucleosome passage
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13.07.2022

A Sequential Two-Step Priming Scheme Reproduces Diversity in Synaptic Strength and Short-Term Plasticity

Authors Lin KH, Taschenberger H, Neher E Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207987119. Abstract Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional
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