New technology platform combines high-throughput recordings of cellular electrophysiology of isolated cardiomyocytes and neurons and their optical stimulation with light.
Electrical activity is one of the most important common features of the heart and the brain. The goal of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells (MBExC)” is to understand the functional properties of cardiomyocytes and neurons, which form the smallest electrically active units of both organs.
With the aim of advancing the direct investigation of the electrical activity of isolated cardiomyocytes and neurons, a technology platform has recently been established at the MBExC that uniquely enables high-throughput measurements of cellular electrophysiology. The platform is headed by MBExC associated investigator Prof. Dr. Niels Voigt from the Institute of Pharmacology and Toxicology at the University Medical Center Göttingen (UMG) and MBExC optogenetics application specialist Dr. Thomas Mager from the Institute for Auditory Neuroscience at the UMG.