2021

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City-Light poster campaign at Wilhelmsplatz, Göttingen Photo: Fritz Kobe, MBExC, UMG

27.08.2021

The MBExC starts City Light poster campaign

Over the next 12 months, the MBExC will be present at Göttingen, Wilhelmsplatz with a series of six beautifully illustrated and illuminated City Light posters to engage and inspire people about the pioneering heart and brain research and the amazing scientists at the MBExC. This poster series is accompanied by
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26.08.2021

Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation

Authors Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2021 Aug 26;56:102518. Abstract CRISPR/Cas9 technology based on nuclease inactive dCas9 and fused to the heterotrimeric VPR transcriptional activator is a powerful tool to enhance endogenous transcription by targeting defined genomic loci. We
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24.08.2021

The structure of a dimeric form of SARS-CoV-2 polymerase

Authors Jochheim FA, Tegunov D, Hillen HS, Schmitzova J, Kokic G, Dienemann C, Cramer P Journal Communications Biology Citation Commun Biol. 2021 Aug 24;4(1):999. Abstract The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed
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MBExC X-ray Symposium 2021 at Paulinerkirche, Göttingen Photo: Fritz Kobe, MBExC, UMG

23.08.2021

MBExC X-ray Symposium in person

After a long time of only ZOOM meetings, the international MBExC Symposium “X-ray based imaging on different scales for biomedical application” took place again in person last Monday, with a limited number of participants, but was also streamed on Göttingen campus. The symposium was organized by Frauke Alves, Tim Salditt
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20.08.2021

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Authors Santos GL, Meyer T, Tiburcy M, DeGrave A, Zimmermann WH, Lutz S Journal Journal of Visualized Experiments Citation J Vis Exp. 2021 Aug 20;(174). Abstract Fibroblasts are phenotypically highly dynamic cells, which quickly transdifferentiate into myofibroblasts in response to biochemical and biomechanical stimuli. The current understanding of fibrotic processes,
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20.08.2021

Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model

Authors Oestreicher D, Picher MM, Rankovic V, Moser T, Pangrsic T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 2021, 14:689415. Abstract Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. However, future gene therapy promises restoration of
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The antiviral drug candidate molnupiravir (yellow) is incorporated into the viral RNA, where it leads to mutations (purple) that ultimately prevent the virus from replicating. Florian Kabinger, Christian Dienemann and Patrick Cramer @MPI-BPC

16.08.2021

Molecular mechanisms of corona drug candidate Molnupiravir unraveled

The United States recently secured 1.7 million doses of a compound that could help to treat Covid-19 patients. In preliminary studies, Molnupiravir reduced the transmission of the SARS-CoV-2 coronavirus. Studies, including work by MBExC member Patrick Cramer at the MPI for Biophysical Chemistry and researchers at JMU Würzburg, showed why
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13.08.2021

MFSD2A-associated primary microcephaly – Expanding the clinical and mutational spectrum of this ultra-rare disease

Authors Khuller K, Yigit G, Grijalva CM, Altmüller J, Thiele H, Nürnberg P, Elcioglu NH, Yeter B, Hehr U, Stein A, Della Marina A, Köninger A, Depienne C, Kaiser FJ, Wollnik B, Kuechler A Journal European Journal of Medical Genetics Citation Eur J Med Genet. 2021 Aug 13:104310. Abstract MFSD2A,
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13.08.2021

Impaired Exercise Tolerance in Repaired Tetralogy of Fallot Is Associated With Impaired Biventricular Contractile Reserve: An Exercise-Stress Real-Time Cardiovascular Magnetic Resonance Study

Authors Steinmetz M, Stümpfig T, Seehase M, Schuster A, Kowallick J, Müller M, Unterberg-Buchwald C, Kutty S, Lotz J, Uecker M, Paul T Journal Circulation: Cardiovascular Imaging Citation Circ Cardiovasc Imaging. 2021 Aug;14(8):e011823. Abstract Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular
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11.08.2021

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Authors Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2021). 2021 Aug 11. Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of
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