2021

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Prof. Dr. Patrick Cramer© Irene Bötther-Gajewski / Max-Planck-Institut für biophysikalische Chemie

15.09.2021

Patrick Cramer receives Aminoff Prize

MBExC member Patrick Cramer was awarded this year’s Aminoff Prize together with Elena Conti, Germany, and Seth Darst, USA, for the investigation of cellular systems for the production, transport and quality control of RNA. The Gregori Aminoff Prize of the Royal Swedish Academy of Sciences honors every year scientific advances in
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08.09.2021

Instant three-color multiplane fluorescence microscopy

Authors Gregor I, Butkevich E, Enderlein J, Mojiri S Journal Biophysical Reports Citation Biophysical Reports 1 (1), 8 Sep 2021, 100001. Abstract One of the most widely used microscopy techniques in biology and medicine is fluorescence microscopy, offering high specificity in labeling as well as maximal sensitivity. For live-cell imaging,
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A rendering of the three-dimensional model of mtRNase P is depicted in the foreground with protein subunits in grey and RNA in red, and the typical cristae-structure of mitochondrial membranes and associated protein complexes are depicted in the background. © Arjun Bhatta / MPI-BPC

06.09.2021

How RNAs are made-to-measure to power our cells

Mitochondria are organelles within our cells that generate the majority of chemical energy required to sustain life. They contain a dedicated genome with a special set of genes that need to be expressed to fulfill their function. An important step in mitochondrial gene expression is RNA processing, during which the
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06.09.2021

Structural basis of RNA processing by human mitochondrial RNase P

Authors Bhatta A, Dienemann C, Cramer P, Hillen HS Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol (2021). Abstract Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species.
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01.09.2021

The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1

Authors Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK Journal Physiological Reports Citation Physiol Rep. 2021 Sep;9(18):e15030. Abstract Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited arrhythmogenic disorder caused by missense mutations in the cardiac ryanodine receptors (RyR2), that result in increased β-adrenoceptor stimulation-induced
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The German science podcast of all Clusters of Excellence "Exzellent erklärt – Spitzenforschung für alle".

01.09.2021

Clusters of Excellence launches joint podcast series

On September 1, 2021, the first episode of the German science podcast series “Exzellent erklärt – Spitzenforschung für alle” will be released. The podcast on current science topics reflects the research diversity of all 57 Clusters of Excellence, funded by the Deutsche Forschungsgemeinschaft: from Africa Studies to Future of Medicine.
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City-Light poster campaign at Wilhelmsplatz, Göttingen Photo: Fritz Kobe, MBExC, UMG

31.08.2021

MBExC starts City-Light poster campaign

Over the next 12 months, the MBExC will be present at Göttingen, Wilhelmsplatz with a series of six beautifully illustrated and illuminated City Light posters to engage and inspire people about the pioneering heart and brain research and the amazing scientists at the MBExC. This poster series is accompanied by
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30.08.2021

Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons

Authors Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO Journal Scientific Reports Citation Sci Rep. 2021 Aug 30;11(1):17374. Abstract A strong focus on sex-related differences has arisen recently in neurobiology, but most investigations focus on brain function in vivo, ignoring common experimental models like cultured neurons.
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EMIM 2021 Opening Session with Prof. Dr. Wolfgang Brück, Björn Thümler, Prof. Dr. Frauke Alves and Prof. Dr. Metin Tolan Photo: M. Weilandt

27.08.2021

Joint session of MBExC and iFIT at EMIM 2021

The MBExC presented research highlights at the EMIM 2021 within a shared session with the Cluster of Excellence iFIT at the EMIM2021 symposium. MBExC member Prof. Dr. Frauke Alves has brought this exciting symposium to Göttingen as the acting president of the European Society for Molecular Imaging (ESMI), which was
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27.08.2021

Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo

Authors Thom T, Schmitz M, Fischer AL, Correia A, Correia S, Llorens F, Pique AV, Möbius W, Domingues R, Zafar S, Stoops E, Silva CJ, Fischer A, Outeiro TF, Zerr I Journal Movement Disorders Citation Mov Disord. 2021 Aug 27. Abstract Background The cellular prion protein (PrPC) is a membrane-bound,
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