2021

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05.03.2021

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors

Authors Martinez-Sanchez A, Laugks U, Kochovski Z, Papantoniou C, Zinzula L, Baumeister W, Lučić V Journal Science Advances Citation Sci Adv. 2021 Mar 5;7(10):eabe6204. Abstract   Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported
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In the cochlea of the inner ear, sound waves are detected in a frequency-specific manner and subsequently transmitted to the brain. Image @ Christian Vogl, Carlos Duque Afonso, Tobias Moser, Institute for Auditory Neuroscience, UMG, 2017.

03.03.2021

Radio broadcast on the World Hearing Day

On the World Hearing Day, Prof. Dr. Dirk Beutner from the Department of Otorhinolaryngology, UMG Göttingen and Dr. Marcus Jeschke from the Cognitive Hearing in Primates group at the German Primate Center and UMG are talking about hearing at the Stadtradio Göttingen broadcast “Mittendrin”, organized by the MBExC in collaboration
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03.03.2021

An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

Authors Bartsch A, Ives CM, Kattner C, Pein F, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C, Llabrés S Journal Biochimica et Biophysica Acta – Biomembranes Citation Biochim Biophys Acta Biomembr. 2021 Mar 3:183601. Abstract Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To cross the
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01.03.2021

Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity

Authors Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB Journal Frontiers in Aging Neuroscience Citation Front Aging Neurosci. 2021 Mar 22;13:635760. Abstract Tauopathies are neurodegenerative disorders with increasing incidence
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01.03.2021

Molecular and cellular dynamics of the 26S proteasome

Authors Sakata E, Eisele MR, Baumeister W Journal Biochimica et Biophysica Acta – Proteins and Proteomics Citation Biochim Biophys Acta Proteins Proteom. 2021 Mar;1869(3):140583. Epub 2020 Dec 13. Abstract In eukaryotic cells, the ubiquitin-proteasome system serves to remove proteins that are either dysfunctional or no longer needed. The 26S proteasome
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A team led by Prof. Dr. André Fischer (reserach group leader at the DZNE Göttingen site, Professor at the Department of Psychiatry and Psychotherapy at the UMG and MBExC member; photo:private) and Prof. Dr. Karl Toischer (Department of Cardiology and Pneumology at the UMG and DZHK Göttingen site; photo: umg/hzg) has found evidence of disturbed gene activity in the brain as a result of heart problems.

26.02.2021

A weak heart links to memory impairment

Heart problems cause disturbed gene activity in the brain’s memory center, from which cognitive deficits arise. A team led by Prof. Dr. André Fischer (reserach group leader at the DZNE Göttingen site, Professor at the Department of Psychiatry and Psychotherapy at the UMG and MBExC member) and Prof. Dr. Karl
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24.02.2021

Emerging concepts in synucleinopathies

Authors Outeiro TF Journal Acta Neuropathologica (Editorial) Citation Acta Neuropathol. 2021 Feb 24. Abstract No abstract available DOI 10.1007/s00401-021-02290-7 Pubmed Link  
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Viola Priesemann Photo: Horst Ziegenfusz

18.02.2021

Communitas Prize for Viola Priesemann

The Max Planck Society honors the physicist and MBExC member Dr. Viola Priesemann for her science communication during the Corona pandemic, where she advises politicians, gives interviews, writes statements and publishes her scientific work in prestigious journals. Since the beginning of the pandemic, Viola Priesemann has been calculating scenarios of
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16.02.2021

Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

Authors Zhang Y, Dijkman PM, Zou R, Zandl-Lang M, Sanchez RM, Eckhardt-Strelau L, Köfeler H, Vogel H, Yuan S, Kudryashev M Journal Nature Communications Citation Nat Commun. 2021 Feb 16;12(1):1074. Abstract Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the
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15.02.2021

Monitoring mitochondrial translation in living cells

Authors Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D Journal EMBO Reports Citation EMBO Rep. 2021 Feb 15:e51635. Abstract Mitochondria possess a small genome that codes for core subunits of the oxidative phosphorylation system and whose expression is essential for energy production.
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