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14.10.2021

Loss of Mitochondrial Ca2+ Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy

Authors Bertero E, Nickel A, Kohlhaas M, Hohl M, Sequeira V, Brune C, Schwemmlein J, Abeßer M, Schuh K, Kutschka I, Carlein C, Münker K, Atighetchi S, Müller A, Kazakov A, Kappl R, von der Malsburg K, van der Laan M, Schiuma AF, Böhm M, Laufs U, Hoth M, Rehling
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13.10.2021

Bucky Ball Is a Novel Zebrafish Vasa ATPase Activator

Authors Perera RP, Shaikhqasem A, Rostam N, Dickmanns A, Ficner R, Tittmann K, Dosch R Journal Biomolecules Citation Biomolecules. 2021; 11(10):1507. Abstract Many multicellular organisms specify germ cells during early embryogenesis by the inheritance of ribonucleoprotein (RNP) granules known as germplasm. However, the role of complex interactions of RNP granules
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Prof. Dr. André FischerPhoto: private

11.10.2021

Researchers find warning signs for dementia in the blood

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. The biomarker described by the team led by MBExC member Prof. André Fischer is based on measuring levels of so-called microRNAs. According to
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11.10.2021

A microRNA signature that correlates with cognition and is a target against cognitive decline

Authors Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka
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11.10.2021

Familial cleft tongue caused by a unique translation initiation codon variant in TP63

Authors Schmidt J, Schreiber G, Altmüller J, Thiele H, Nürnberg P, Li Y, Kaulfuß S, Funke R, Wilken B, Yigit G, Wollnik B Journal European Journal of Human Genetics Citation Eur J Hum Genet. 2021 Oct 11. Abstract Variants in transcription factor p63 have been linked to several autosomal dominantly
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08.10.2021

Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501

Authors Goldberg M, Islam MR, Kerimoglu C, Lancelin C, Gisa V, Burkhardt S, Krüger DM, Marquardt T, Malchow B, Schmitt A, Falkai P, Sananbenesi F, Fischer A Journal Translational Psychiatry Citation Transl Psychiatry. 2021 Oct 8;11(1):514. Abstract MicroRNAs have been linked to synaptic plasticity and memory function and are emerging
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08.10.2021

Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis

Authors Lavdovskaia E, Hillen HS, Richter-Dennerlein R Journal Trends in Cell Biology Citation Trends Cell Biol. 2021. Abstract Final maturation steps during ribo-some biogenesis require the assis-tance of assembly and qualitycontrol factors to ensure the foldingof rRNA and proteins into a func-tional translation machinery. Herewe integrate several recent struc-tural snapshots
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Prof. Dr. André Fischer

08.10.2021

Jan Huisken takes up Humboldt-Professorship

The MBExC warmly welcomes its new member Humboldt-Professor Dr. Jan Huisken! The co-founder of modern light-sheet microscopy and world leader in the field of multiscale imaging strengthens research at the MBExC, the University of Göttingen, and the Göttingen Campus. Link to the press release Watch this video on YouTube
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Prof. Dr. André Fischer

08.10.2021

Jan Huisken takes up Humboldt-Professorship

Physicist strengthens MBExC research program in the field of multiscale biology. (mbexc/pug/umg) Physicist Prof. Dr. Jan Huisken has taken up his Alexander von Humboldt Professorship at the University of Göttingen. He was awarded the prestigious chair after successful nomination by the University in November last year. As a member of
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07.10.2021

The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

Authors Grabner CP, Moser T Journal Elife Citation Elife. 2021 Oct 7;10:e63844. Abstract Rod photoreceptors (PRs) use ribbon synapses to transmit visual information. To signal ‘no light detected’ they release glutamate continually to activate post-synaptic receptors. When light is detected glutamate release pauses. How a rod’s individual ribbon enables this
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