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A rendering of the three-dimensional model of mtRNase P is depicted in the foreground with protein subunits in grey and RNA in red, and the typical cristae-structure of mitochondrial membranes and associated protein complexes are depicted in the background. © Arjun Bhatta / MPI-BPC

06.09.2021

How RNAs are made-to-measure to power our cells

Mitochondria are organelles within our cells that generate the majority of chemical energy required to sustain life. They contain a dedicated genome with a special set of genes that need to be expressed to fulfill their function. An important step in mitochondrial gene expression is RNA processing, during which the
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06.09.2021

Structural basis of RNA processing by human mitochondrial RNase P

Authors Bhatta A, Dienemann C, Cramer P, Hillen HS Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol (2021). Abstract Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species.
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01.09.2021

The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1

Authors Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK Journal Physiological Reports Citation Physiol Rep. 2021 Sep;9(18):e15030. Abstract Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited arrhythmogenic disorder caused by missense mutations in the cardiac ryanodine receptors (RyR2), that result in increased β-adrenoceptor stimulation-induced
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The German science podcast of all Clusters of Excellence "Exzellent erklärt – Spitzenforschung für alle".

01.09.2021

Clusters of Excellence launches joint podcast series

On September 1, 2021, the first episode of the German science podcast series “Exzellent erklärt – Spitzenforschung für alle” will be released. The podcast on current science topics reflects the research diversity of all 57 Clusters of Excellence, funded by the Deutsche Forschungsgemeinschaft: from Africa Studies to Future of Medicine.
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