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Michael Weber, Prof. Dr. Stefan Hell, and Dr. Marcel Leutenegger (from left)© Irene Böttcher-Gajewski / Max Planck Institute for Biophysical Chemistry

17.03.2021

MINSTED resolves fluorescent molecules with resolution at the nanometer scale

Scientists working with MBExC member Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the Heidelberg-based MPI for Medical Research have developed another light microscopy method, called MINSTED, which resolves fluorescently labeled details with molecular sharpness. With MINSTED, Nobel laureate Hell has come full circle.
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17.03.2021

MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile

Authors Jacinto S, Guerreiro P, de Oliveira RM, Cunha-Oliveira T, Santos MJ, Grazina M, Rego AC, Outeiro TF Journal Frontiers in Cellular Neuroscience Citation Front Cell Neurosci. 2021 Mar 17;15:641264. Abstract Mutations in the MPV17 gene are associated with hepatocerebral form of mitochondrial depletion syndrome. The mechanisms through which MPV17
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16.03.2021

Presynaptic activity and protein turnover are correlated at the single-synapse level

Authors Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V Journal Cell Reports Citation Cell Reports 34, 108841, March 16, 2021. Abstract Synaptic transmission relies on the continual exocytosis and recycling of synaptic vesicles. Aged vesicle proteins are prevented from recycling
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15.03.2021

Non-negative Matrix Factorization as a Tool to Distinguish Between Synaptic Vesicles in Different Functional States

Authors Neher E, Taschenberger H Journal Neuroscience Citation Neuroscience. 2021 Mar 15;458:182-202. Abstract Synaptic vesicles (SVs) undergo multiple steps of functional maturation (priming) before being fusion competent. We present an analysis technique, which decomposes the time course of quantal release during repetitive stimulation as a sum of contributions of SVs,
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15.03.2021

MINSTED fluorescence localization and nanoscopy

Authors Weber M, Leutenegger M, Stoldt S, Jakobs S, Mihaila TS, Butkevich AN, Hell SW Journal Nature Photonics Citation Nat. Photonics 15, 361–366 (2021). Abstract We introduce MINSTED, a fluorophore localization and super-resolution microscopy concept based on stimulated emission depletion (STED) that provides spatial precision and resolution down to the
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Photo above: © Johannes Pauly / Max Planck Institute for Biophysical Chemistry Photo below: © Max Planck Institute for Experimental Medicine

15.03.2021

Two Max Planck Institutes in Göttingen become one

The Max Planck Institutes (MPI) for Biophysical Chemistry and for Experimental Medicine will merge. The decision-making bodies of the Max Planck Society (MPS) approved the plan submitted by the two institutes on March 12. Formally, both institutions will be closed and a new MPI will be founded, keeping the existing
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WoCaNet 2021 Logo

15.03.2021

Register now for the Women’s Carrers and Networks 2021

Until April 30th, 2021 you can register for the next virtual Women’s Careers and Networking symposium (WoCaNet 2021) taking place from the 27th to the 28th of the coming May. The aim of WoCaNet is to provide an interactive environment for young female scientists to find new possibilities and networking
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Prof. Dr. Jutta GärtnerFoto: umg/kimmel

12.03.2021

Jutta Gärtner successful with DZKJ satellite Göttingen

The Federal Ministry of Education and Research (BMBF) has selected the University Medical Center Göttingen and other scientific partner institutions from Göttingen as new satellite location for the German Centre for Child and Adolescent Health (DZKJ). Prof. Dr. Jutta Gärtner, Director of the Department of Paediatrics and Adolescent Medicine, UMG
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11.03.2021

Developing fast, red-light optogenetic stimulation of spiral ganglion neurons for future optical cochlear implants

Authors Huet AT, Dombrowsik T, Rankovic V, Thirumalai A, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:635897. Abstract Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical
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08.03.2021

Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control

Authors Hoffmann S, Schmitteckert S, Raedecke K, Rheinert D, Diebold S, Roeth R, Weiss B, Granzow M, Niesler B, Griesbeck A, Eckstein V, Zimmermann WH, Just S, Rappold GA Journal Biochimica et Biophysica Acta – Gene Regulatory Mechanisms Citation Biochim Biophys Acta Gene Regul Mech. 2021 Mar 8:194702. Abstract The
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