February

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A team led by Prof. Dr. André Fischer (reserach group leader at the DZNE Göttingen site, Professor at the Department of Psychiatry and Psychotherapy at the UMG and MBExC member; photo:private) and Prof. Dr. Karl Toischer (Department of Cardiology and Pneumology at the UMG and DZHK Göttingen site; photo: umg/hzg) has found evidence of disturbed gene activity in the brain as a result of heart problems.

26.02.2021

A weak heart links to memory impairment

Heart problems cause disturbed gene activity in the brain’s memory center, from which cognitive deficits arise. A team led by Prof. Dr. André Fischer (reserach group leader at the DZNE Göttingen site, Professor at the Department of Psychiatry and Psychotherapy at the UMG and MBExC member) and Prof. Dr. Karl
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24.02.2021

Emerging concepts in synucleinopathies

Authors Outeiro TF Journal Acta Neuropathologica (Editorial) Citation Acta Neuropathol. 2021 Feb 24. Abstract No abstract available DOI 10.1007/s00401-021-02290-7 Pubmed Link  
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Viola Priesemann Photo: Horst Ziegenfusz

18.02.2021

Communitas Prize for Viola Priesemann

The Max Planck Society honors the physicist and MBExC member Dr. Viola Priesemann for her science communication during the Corona pandemic, where she advises politicians, gives interviews, writes statements and publishes her scientific work in prestigious journals. Since the beginning of the pandemic, Viola Priesemann has been calculating scenarios of
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16.02.2021

Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

Authors Zhang Y, Dijkman PM, Zou R, Zandl-Lang M, Sanchez RM, Eckhardt-Strelau L, Köfeler H, Vogel H, Yuan S, Kudryashev M Journal Nature Communications Citation Nat Commun. 2021 Feb 16;12(1):1074. Abstract Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the
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15.02.2021

Monitoring mitochondrial translation in living cells

Authors Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D Journal EMBO Reports Citation EMBO Rep. 2021 Feb 15:e51635. Abstract Mitochondria possess a small genome that codes for core subunits of the oxidative phosphorylation system and whose expression is essential for energy production.
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12.02.2021

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Authors Brás IC, Outeiro TF Journal Cells Citation Cells 2021, 10(2), 375. Abstract The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis. The stereotypical distribution and evolution of the pathology during disease is often attributed to the cell-to-cell
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11.02.2021

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life (Basel). 2021 Feb 11;11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of
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11.02.2021

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life. 2021; 11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination
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11.02.2021

Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling

Authors Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2021 Feb 11:100061. Abstract Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming
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10.02.2021

The Coding And Small-Non-Coding Hippocampal Synaptic RNAome

Authors Epple R, Krüger D, Berulava T, Brehm G, Ninov M, Islam R, Köster S, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Feb 10. Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more
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