January

Authors Backhaus SJ, Lange T, George EF, Hellenkamp K, Gertz RJ, Billing M, Wachter R, Steinmetz M, Kutty S, Raaz U, Lotz J, Friede T, Uecker M, Hasenfuß G, Seidler T, Schuster A Journal Circulation Citation Circulation. 2021 Jan 21. Abstract Background: Right heart catheterisation (RHC) using exercise-stress is the

Authors Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 Jan 20:e11900. Abstract In current clinical practice, care

Authors Pofantis E, Neher E, Dresbach T Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022551118. Abstract Neurotransmitter release occurs by regulated exocytosis from synaptic vesicles (SVs). Evolutionarily conserved proteins mediate the essential aspects of this process, including the membrane

Authors Hofemeier AD, Limón T, Muenker TM, Wallmeyer B, Jurado A, Afshar ME, Ebrahimi M, Tsukanov R, Oleksiievets N, Enderlein J, Gilbert PM, Betz T Journal Elife Citation Elife. 2021 Jan 18;10:e60145. Abstract Tension and mechanical properties of muscle tissue are tightly related to proper skeletal muscle function, which makes

Authors Lidschreiber K, Jung LA, von der Emde H, Dave K, Taipale J, Cramer P, Lidschreiber M Journal Molecular Systems Biology Citation Mol Syst Biol. 2021 Jan;17(1):e9873. Abstract The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Here, we use transient transcriptome sequencing (TT-seq)

Authors Thomas C, Cavazza T, Schuh M Journal Biochemical Society Transactions Citation Biochem Soc Trans. 2021 Jan 15:BST20200043. Abstract Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from

Authors Zhang S, Aibara S, Vos SM, Agafonov DE, Lührmann R, Cramer P Journal Science Citation Science. 2021 Jan 15;371(6526):305-309. Abstract To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo–electron

Authors So C, Cheng S, Schuh M Journal Trends in Cell Biology Citation Trends in Cell Biology, Jan 2021, online. Abstract Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work

Authors Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G Journal Cell Reports Citation Cell Rep. 2021 Jan 12;34(2):108623. Abstract Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear.