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30.07.2020

Dopamine promotes the neurodegenerative potential of β-synuclein

Authors Raina A, Leite K, Guerin S, Mahajani SU, Chakrabarti KS, Voll D, Becker S, Griesinger C, Bähr M, Kügler S Journal Journal of Neurochemistry Citation J Neurochem. 2020 Jul 30. Abstract A contribution of α-Synuclein (α-Syn) to etiology of Parkinson´s disease (PD) and Dementia with Lewy bodies (DLB) is
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30.07.2020

Effects of pharmacological modulators of α‐synuclein and tau aggregation and internalization

Authors Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF Journal Scientific Reports Citation Sci Rep 10, 12827 (2020). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect
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Snapshot of protein mobility in the synapse. A region within the synapse at the edge of the synaptic vesicle cluster is shown. Organelles in grey represent synaptic vesicles (each ~40 nm in diameter). Various shapes correspond to different protein molecules, with each protein species having its own shape, as extracted from stuctural studies. The proteins are colored based on the speed of movement of every individual molecule in every position, from dark violet (the slowest one) to yellow (the fastest). Most proteins move slowly next to the synaptic vesicles, and are much faster in the vesicle-free region. Source: Reshetniak and co-authors

30.07.2020

In one sweep: Visualization of protein mobility in the synapse

A team of scientists around Prof. Dr. Silvio O. Rizzoli and Prof. Dr. Sarah Köster was able to generate the first visualizations of movement of 45 proteins in a cell simultaneously, thus demonstrating the realistic mobility of thousands of protein molecules represented in their realistic shapes and sizes within a
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Snapshot of protein mobility in the synapse. A region within the synapse at the edge of the synaptic vesicle cluster is shown. Organelles in grey represent synaptic vesicles (each ~40 nm in diameter). Various shapes correspond to different protein molecules, with each protein species having its own shape, as extracted from stuctural studies. The proteins are colored based on the speed of movement of every individual molecule in every position, from dark violet (the slowest one) to yellow (the fastest). Most proteins move slowly next to the synaptic vesicles, and are much faster in the vesicle-free region. Source: Reshetniak and co-authors

30.07.2020

In one sweep: Visualization of protein mobility in the synapse

(mbexc/umg) All functions of the neural system, including body movements, sensory reactions, and information processing in the brain, depend on the constant and controlled communication between nerve cells. The contact sites between nerve cells, the synapses, have been extensively studied over the last decades, extending our understanding of brain functioning
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