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08.06.2020

CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response

Authors Stik G, Vidal E, Barrero M, Cuartero S, Vila-Casadesús M, Mendieta-Esteban J, Tian TV, Choi J, Berenguer C, Abad A, Borsari B, le Dily F, Cramer P, Marti-Renom MA, Stadhouders R, Graf T Journal Nature Genetics Citation Nat Genet. 2020 Jul;52(7):655-661. Abstract Three-dimensional organization of the genome is important
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05.06.2020

Fluorescence polarization filtering for accurate single molecule localization

Authors Nevskyi O, Tsukanov R, Gregor I, Karedla N, Enderlein J Journal APL Photonics Citation APL Photonics 5, 061302 (2020). Abstract Single-Molecule Localization Microscopy (SMLM) has become one of the most important methods of super-resolution fluorescencemicroscopy. It is based on the precise localization of single molecules in wide-field microscopy images.
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03.06.2020

Generation of Engineered Human Myocardium in a Multi-well Format

Authors Tiburcy M, Meyer T, Liaw NY, Zimmermann WH Journal STAR protocols Citation STAR Protoc. 2020 Jun 3;1(1):100032. Abstract This protocol describes a robust method for the generation of engineered human myocardium (EHM) from pluripotent stem cells (PSCs) in a multi-well plate under defined, serum-free conditions. By parallel culture of
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02.06.2020

Empirical regularized optimal transport: Statistical theory and applications

Authors Klatt M, Tameling C, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 2 (2), 419-443. Abstract We derive limit distributions for various empirical regularized optimal transport quantities between probability distributions supported on a finite metric space and show their
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02.06.2020

The essential histogram

Authors Li H, Munk A, Sieling H, Walther G Journal Biometrika Citation Biometrika (2020), 107, 2, pp. 347–364 Abstract The histogram is widely used as a simple, exploratory way of displaying data, but it is usually not clear how to choose the number and size of the bins. We construct
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01.06.2020

A Nanobody-Based Fluorescent Reporter Reveals Human α-Synuclein in the Cell Cytosol

Authors Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, Becker S, Rizzoli SO, Basmanav FB, Opazo F Journal Nature Communications Citation Nat Commun. 2020 Jun 1;11(1):2729. Abstract Aggregation and spreading of α-Synuclein (αSyn) are hallmarks of several neurodegenerative diseases, thus monitoring human αSyn (hαSyn) in animal models or cell cultures is vital for the field. However,
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01.06.2020

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome

Authors Drivas TG, Li D, Nair D, Alaimo JT, Alders M, Altmuller J, Barakat TS, Bebin EM, Bertsch NL, Blackburn PR, Blesson A, Bouman AM, Brockmann K, Brunelle P, Burmeister M, Cooper GM, Denecke J, … Wollnik B, et al. Journal European Journal of Human Genetics Citation Eur J Hum
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