Hertha Sponer College Advanced Methods Course

Hertha Sponer College Advanced Methods Course (Internal Event)

Automated patch-clamp measurements – SyncroPatch: Human iPSC-derived cardiomyocytes

Alterations in disease-relevant nanoscale functional units of cardiac plasmalemmal ion channels often translate into abnormal channel function, which can manifest in patients as severe diseases with adverse clinical outcomes such as cardiac arrhythmias. Human iPSC derived cardiomyocytes represent a useful and abundant model to study electrophysiology in health or disease. In this workshop, we will utilise a state-of-the art automated patch clamp device, The SyncroPatch 384, to directly assess real time ionic channel function of human iPSC derived cardiomyocytes. This workshop will also include a brief overview about the patch clamp technique and its potential applications in patient-tailored treatment of cardiac diseases.

Monday, 22 May 2023, 2 – 5 p.m., DZHK building Robert Koch-Str. 42 a

Supervisor: Thomas Mager, MBExC Application Specialist; Institute for Auditory Neuroscience, UMG & Alexey Alekseev, Institute for Auditory Neuroscience, UMG & Fitzwilliam Seibertz, Inst. of Pharmacology & Toxicology, RG Molecular Pharmacology, UMG