Wolf, Fred

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11.06.2025

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Authors Harris SS, Rajani RM, Zünkler J, Ellingford R, Yang M, Rowland JM, Schmidt A, Lee BI, Kehring M, Hellmuth M, Lam FKW, Fässler D, Erdinger S, Wolfer DP, Sala Frigerio C, Wolf F, Hyman BT, Müller UC, Busche MA Journal Cell Reports Citation Cell Rep. 2025 Jun 11;44(6):115801. Abstract
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25.04.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal BioRxiv Citation bioRxiv 2025.04.22.649963. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with remarkable fidelity. To achieve
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23.04.2025

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

Authors Harris SS, Ellingford R, Hartmann J, Dasgupta D, Kehring M, Rajani RM, Graykowski D, Quittot N, Sivasankaran D, Commins C, Fan Z, Bond SA, Wolf F, Dupret D, Dolan RJ, Konnerth A, Neef A, Hyman BT, Busche MA Journal Cell Citation Cell. 2025 Apr 23:S0092-8674(25)00408-8. Abstract Tau accumulation is
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15.04.2025

Synchronization in epithelial tissue morphogenesis

Authors Richa P, Häring M, Wang Q, Choudhury AR, Göpfert MC, Wolf F, Großhans J, Kong D Journal Current Biology Citation Curr Biol. 2025 Apr 11:S0960-9822(25)00382-3. Abstract Coordination of cell behavior is central to morphogenesis, when arrays of cells simultaneously undergo shape changes or dynamic rearrangements. In epithelia, cell shape
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29.01.2025

Cortical population coding critically depends on fine-tuning of cell physiology

Authors Revah O, Wolf F, Gutnick MJ, Neef A Journal Biorxiv Citation bioRxiv 2024.02.15.580451. Abstract Cortical function reflects the activities of populations of neurons. How accurately they can encode information depends on the speed with which each neuron can respond to input, as revealed by dynamic gain analysis. Theory predicts
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14.01.2025

Single neuron diversity supports area functional specialization along the visual cortical pathways

Authors Feyerabend M, Pommer S, Jimenez-Sosa MS, Rachel J, Sunstrum JK, Preuss F, Mestern S, Hinkel R, Mietsch M, Viyajraghavan S, Everling S, Treue S, Arnsten AFT, Lewis DA, Wolf F, Murray J, Muller L, McCarroll S, Krienen F, Datta D, Jing Wang X, Tripathy S, Gonzalez-Burgos G, Inoue W,
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30.12.2024

Sparse chaos in cortical circuits

Authors Engelken R, Monteforte M, Wolf F   Journal Arxiv   Citation arXiv:2412.21188.   Abstract Nerve impulses, the currency of information flow in the brain, are generated by an instability of the neuronal membrane potential dynamics. Neuronal circuits exhibit collective chaos that appears essential for learning, memory, sensory processing, and
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19.12.2024

An Analytically Solvable Model of Firing Rate Heterogeneity in Balanced State Networks

Authors Schmidt A, Hiemeyer P, Wolf F Journal Arxiv Citation arXiv:2305.13420. Abstract Distributions of neuronal activity within cortical circuits are often found to display highly skewed shapes with many neurons emitting action potentials at low or vanishing rates, while some are active at high rates. Theoretical studies were able to
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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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27.03.2024

Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding

Authors Zhang C, Revah O, Wolf F, Neef A Journal Journal of Neuroscience Citation J Neurosci. 2024 Mar 27;44(13):e0799232023. Abstract Modern, high-density neuronal recordings reveal at ever higher precision how information is represented by neural populations. Still, we lack the tools to understand these processes bottom-up, emerging from the biophysical
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