Urlaub, Henning

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30.11.2023

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

Authors Altas B, Rhee HJ, Ju A, Solís HC, Karaca S, Winchenbach J, Kaplan-Arabaci O, Schwark M, Ambrozkiewicz MC, Lee C, Spieth L, Wieser GL, Chaugule VK, Majoul I, Hassan MA, Goel R, Wojcik SM, Koganezawa N, Hanamura K, Rotin D, Pichler A, Mitkovski M, de Hoz L, Poulopoulos A,
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06.11.2023

Structure of the transcribing RNA polymerase II-Elongin complex

Authors Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2023 Nov 6. Abstract Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM
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30.10.2023

Mammalian oocyes store proteins for the early embryo on cytoplasmic lattices

Authors Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh Journal Cell Citation Cell, 2023,
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26.10.2023

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

Authors Binotti B, Ninov M, Cepeda AP, Ganzella M, Matti U, Riedel D, Urlaub H, Sambandan S, Jahn R Journal Autophagy Citation Autophagy. 2023 Oct 26:1-19. Abstract In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane
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29.09.2023

Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase

Authors Egbert JR, Silbern I, Uliasz TF, Lowther KM, Yee SP, Urlaub H, Jaffe LA Journal Biology of Reproduction Citation Biol Reprod. 2023 Sep 29:ioad130. Abstract In response to luteinizing hormone, multiple proteins in rat and mouse granulosa cells are rapidly dephosphorylated, but the responsible phosphatases remain to be identified.
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05.09.2023

Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

Authors Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB Journal Nature Communications Citation Nat Commun. 2023 Sep 5;14(1):5395. Abstract The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility and fertilization via HCO3−-stimulated cAMP synthesis. A complex
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16.08.2023

A viral ADP-ribosyltransferase attaches RNA chains to host proteins

Authors Wolfram-Schauerte M, Pozhydaieva N, Grawenhoff J, Welp LM, Silbern I, Wulf A, Billau FA, Glatter T, Urlaub H, Jäschke A, Höfer K Journal Nature Citation Nature. 2023 Aug 16. Abstract The mechanisms by which viruses hijack the genetic machinery of the cells they infect are of current interest. When
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28.07.2023

Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson’s disease

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a
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26.06.2023

Structural insights into human co-transcriptional capping

Authors Garg G, Dienemann C, Farnung L, Schwarz J, Linden A, Urlaub H, Cramer P Journal Molecular Cell Citation Mol Cell. 2023 Jul 20;83(14):2464-2477.e5. Abstract Co-transcriptional capping of the nascent pre-mRNA 5′ end prevents degradation of RNA polymerase (Pol) II transcripts and suppresses the innate immune response. Here, we provide
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14.06.2023

An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes

Authors Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A Journal Circulation Research Citation Circ Res. 2023 Jun 14.
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