Rehling, Peter

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18.12.2024

A proteome-wide yeast degron collection for the dynamic study of protein function

Authors Valenti R, David Y, Edilbi D, Dubreuil B, Boshnakovska A, Asraf Y, Salame TM, Sass E, Rehling P, Schuldiner M Journal Journal of Cell Biology Citation J Cell Biol. 2025 Feb 3;224(2):e202409050. Abstract Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out.
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24.10.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Silljé HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE Journal PLoS One Citation PLoS One. 2024 Oct 24;19(10):e0311203. Abstract Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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24.08.2024

TOM-TIM23 supercomplex formation

Authors Jain N, Gomkale R, Rehling P Journal Methods in Enzymology Citation Methods Enzymol. 2024;707:3-22. Abstract Mitochondria import the vast majority of proteins from the cytosol. Protein translocation machineries in outer and inner membranes facilitate precursor recognition and transport. Most mitochondrial proteins utilize N-terminal presequences as targeting signals that eventually
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12.08.2024

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Authors Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco
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22.05.2024

Coordinating mitochondrial translation with assembly of the OXPHOS complexes

Authors Kremer LS, Rehling P Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R47-R52. Abstract The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are
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12.05.2024

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

Authors Zung N, Aravindan N, Boshnakovska A, Valenti R, Preminger N, Jonas F, Yaakov G, Willoughby M, Homberg B, Keller J, Kupervaser M, Dezorella N, Dadosh T, Wolf SG, Itkin M, Malitsky S, Brandis A, Barkai N, Fernandez-Busnadiego R, Reddi A, Rehling P, Rapaport D, Schuldiner M Journal BioRxiv Citation
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28.02.2024

Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons

Authors Garg P, Würtz F, Hobbie F, Buttgereit K, Aich A, Leite K, Rehling P, Kügler S, Bähr M   Journal Journal of Neuroinflammation   Citation J Neuroinflammation. 2024 Feb 28;21(1):62.   Abstract Background Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely
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22.01.2024

Drosophila MIC10b can polymerize into cristae-shaping filaments

Authors Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S Journal Life Science Alliance Citation Life Sci Alliance. 2024 Jan 22;7(4):e202302177. Abstract Cristae are invaginations of the mitochondrial inner membrane
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29.12.2023

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although
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