Rehling, Peter

Authors Kuhle B, Krebs L, Bhatta A, Dennerlein S, Rehling P, Hillen H Journal BioRxiv Citation bioRxiv 2026.03.02.709036. Abstract The non-templated addition of the 3′CCA end is the final universal step of tRNA maturation. In humans, 3′CCA addition on nuclear- (nu-tRNA) and mitochondria-encoded tRNAs (mt-tRNA) is catalyzed by a single

Authors Dahal D, Cruz-Zargoza LD, Rehling P Journal Biological Chemistry Citation Biol Chem. 2025 Sep 15. Abstract Mitochondria are essential for cellular metabolism, serving as the primary source of adenosine triphosphate (ATP). This energy is generated by the oxidative phosphorylation (OXPHOS) system located in the inner mitochondrial membrane. Impairments in

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal Nature Communications Citation Nat Commun. 2025 Jul 10;16(1):6391. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are

Authors Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P Journal Science Citation Science. 2025 May 22:eadr3498. Abstract Mitochondria

Authors Boshnakovska A, Pronto JR, Gall T, Aich A, Prochazka J, Nichtova Z, Sedlacek R, Sobitov I, Ainatzi S, Lenz C, Katschinski DM, Urlaub H, Voigt N, Rehling P, Kremer LS Journal Cell Reports Citation Cell Reports, Volume 44, Issue 6, 115723. Abstract Mitochondria are key to cellular energetics, metabolism,

Authors Fenech EJ, Kupervaser M, Boshnakovska A, Ravid S, Gomes Castro I, Asraf Y, Callegari S, Lenz C, Urlaub H, Rehling P, Schuldiner M Journal Contact (Thousand Oaks) Citation Contact (Thousand Oaks). 2025 Apr 17;8:25152564251321770. Abstract Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we

Authors Maurer W, Zieseniss A, Priya VP, Chen Y, Bauer L, Hillemann A, Rehling P, Nanadikar MS, de Zélicourt D, Kurtcuoglu V, Katschinski DM Journal British Journal of Pharmacology Citation Br J Pharmacol. 2025 Apr 15. Abstract Background and purpose: D-amino acid oxidase (DAO) has been developed as a chemogenetic

Authors Jain N, Chacinska A, Rehling P Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2025 Mar 27:S0968-0004(25)00050-7. Abstract Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial

Authors Oborská-Oplová M, Geiger AG, Michel E, Klingauf-Nerurkar P, Dennerlein S, Bykov YS, Amodeo S, Schneider A, Schuldiner M, Rehling P, Panse VG Journal Nature Cell Biology Citation Nat Cell Biol. 2025 Jan 31. Abstract The correct sorting of nascent ribosomal proteins from the cytoplasm to the nucleus or to