Rehling, Peter

Home >> Publications >> Author >> Rehling, Peter
Feature image not available
15.09.2025

Manipulating mitochondrial gene expression

Authors Dahal D, Cruz-Zargoza LD, Rehling P Journal Biological Chemistry Citation Biol Chem. 2025 Sep 15. Abstract Mitochondria are essential for cellular metabolism, serving as the primary source of adenosine triphosphate (ATP). This energy is generated by the oxidative phosphorylation (OXPHOS) system located in the inner mitochondrial membrane. Impairments in
Learn More
Feature image not available
10.07.2025

Super-resolution microscopy of mitochondrial mRNAs

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal Nature Communications Citation Nat Commun. 2025 Jul 10;16(1):6391. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are
Learn More
Feature image not available
22.05.2025

Silencing mitochondrial gene expression in living cells

Authors Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P Journal Science Citation Science. 2025 May 22:eadr3498. Abstract Mitochondria
Learn More
Feature image not available
21.05.2025

SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heart

Authors Boshnakovska A, Pronto JR, Gall T, Aich A, Prochazka J, Nichtova Z, Sedlacek R, Sobitov I, Ainatzi S, Lenz C, Katschinski DM, Urlaub H, Voigt N, Rehling P, Kremer LS Journal Cell Reports Citation Cell Reports, Volume 44, Issue 6, 115723. Abstract Mitochondria are key to cellular energetics, metabolism,
Learn More
Feature image not available
18.04.2025

Profiling the LAM family of contact site tethers provides insights into their regulation and function

Authors Fenech EJ, Kupervaser M, Boshnakovska A, Ravid S, Gomes Castro I, Asraf Y, Callegari S, Lenz C, Urlaub H, Rehling P, Schuldiner M Journal Contact (Thousand Oaks) Citation Contact (Thousand Oaks). 2025 Apr 17;8:25152564251321770. Abstract Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins
Learn More
Feature image not available
17.04.2025

Coupling of ribosome biogenesis and translation initiation in human mitochondria

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we
Learn More
Feature image not available
15.04.2025

D-amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection.

Authors Maurer W, Zieseniss A, Priya VP, Chen Y, Bauer L, Hillemann A, Rehling P, Nanadikar MS, de Zélicourt D, Kurtcuoglu V, Katschinski DM Journal British Journal of Pharmacology Citation Br J Pharmacol. 2025 Apr 15. Abstract Background and purpose: D-amino acid oxidase (DAO) has been developed as a chemogenetic
Learn More
Feature image not available
27.03.2025

Understanding mitochondrial protein import: a revised model of the presequence translocase

Authors Jain N, Chacinska A, Rehling P Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2025 Mar 27:S0968-0004(25)00050-7. Abstract Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial
Learn More
Feature image not available
31.01.2025

An avoidance segment resolves a lethal nuclear-mitochondrial targeting conflict during ribosome assembly

Authors Oborská-Oplová M, Geiger AG, Michel E, Klingauf-Nerurkar P, Dennerlein S, Bykov YS, Amodeo S, Schneider A, Schuldiner M, Rehling P, Panse VG Journal Nature Cell Biology Citation Nat Cell Biol. 2025 Jan 31. Abstract The correct sorting of nascent ribosomal proteins from the cytoplasm to the nucleus or to
Learn More
Feature image not available
31.12.2024

A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

Authors Yousefi R, Cruz-Zaragoza LD, Valpadashi A, Hansohn C, Dahal D, Richter-Dennerlein R, Rizzoli S, Urlaub H, Rehling P, Pacheu-Grau D Journal Cell Reports Citation Cell Rep, 44, 115143. Abstract Mitochondrial DNA encodes 13 subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for
Learn More
X
EN DE
X
X