Hillen, Hauke

Authors Antonicka H, Vučković A, Weraarpachai W, Hong S, Brischigliaro M, Ahn A, Barrientos A, Hillen HS, Shoubridge EA Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jul 8;53(13):gkaf665. Abstract The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we

Authors Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Journal Nature Communications Citation Nat Commun. 2025 Mar 6;16(1):2261. Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its

Authors Ahrens FM, do Prado PFV, Hillen HS, Pfannschmidt T   Journal Trends in Plant Science   Citation Trends Plant Sci. 2025 Feb 25:S1360-1385(25)00031-7.   Abstract Plant chloroplasts possess a dedicated genome (plastome) and a prokaryotic-type plastid-encoded RNA polymerase (PEP) that mediates its expression. PEP is composed of five bacteria-like

Authors Bhatta A, Kuhle B, Yu RD, Spanaus L, Ditter K, Bohnsack KE, Hillen H Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2025). Abstract Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3′ end processing of

Authors Vučković A, Freyer C, Wredenberg A, Hillen HS Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R19-R25. Abstract Human mitochondria harbour a circular, polyploid genome (mtDNA) encoding 11 messenger RNAs (mRNAs), two ribosomal RNAs (rRNAs) and 22 transfer RNAs (tRNAs). Mitochondrial transcription produces long, polycistronic transcripts that

Authors do Prado PFV, Ahrens FM, Liebers M, Ditz N, Braun HP, Pfannschmidt T, Hillen HS   Journal Molecular Cell   Citation Mol Cell (2024) 84, 1–16.   Abstract Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although

Authors Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-Bürgi S, Amberger A, Hillen HS, Zschocke J, Keller MA Journal Cellular and Molecular Life Sciences Citation Cell Mol Life Sci. 2022 Oct 22;79(11):562. Abstract Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms

Authors Bögershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, Hüning I, Polo AM, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, Li