Gollisch, Tim

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07.04.2026

Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies

Authors Sridhar S, Vystrčilová M, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Ecker AS, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2026 Apr 7;22(4):e1014157. Abstract Retinal ganglion cells, the output neurons of the vertebrate retina, often display nonlinear summation of
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19.03.2026

Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Authors Vystrčilová M, Sridhar S, Burg MF, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Gollisch T, Ecker AS Journal eNeuro Citation eNeuro. 2026 Mar 19:ENEURO.0060-26.2026. Abstract The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, and
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09.03.2026

Image modifications reduce differences in natural-image encoding by retinal ganglion cells between natural and optogenetic stimulation

Authors Ramakrishna V, Gollisch T Journal BioRxiv Citation bioRxiv 2026.03.06.710066. Abstract Photoreceptor degeneration is among the leading causes of blindness and optogenetics as a potential therapeutic measure has garnered much attention over recent years. In this approach, light-sensitive molecules like Channelrhodopsin-2 (ChR2) are inserted into neurons in the retina to
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08.09.2025

Interpreting convolutional neural networks to study wide-field amacrine cell inhibition in the retina

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2025.09.08.674839. Abstract Wide-field amacrine cells (ACs) play a unique role in retinal processing by integrating visual information across a large spatial area. Their inhibitory influence has been implicated in multiple retinal functions such as differential
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03.06.2025

Learning to cluster neuronal function

Authors Nellen NS, Turishcheva P, Vystrčilová M, Sridhar S, Gollisch T, Tolias AS, Ecker AS Journal Arxiv Citation arXiv:2506.03293. Abstract Deep neural networks trained to predict neural activity from visual input and behaviour have shown great potential to serve as digital twins of the visual cortex. Per-neuron embeddings derived from
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02.05.2025

Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli

Authors Shahidi N, Rozenblit F, Khani MH, Schreyer HM, Mietsch M, Protti DA, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2025 May 2;21(5):e1013031. Abstract The dichotomy of excitation and suppression is one of the canonical mechanisms explaining the complexity of neural activity. Computational models of the interplay
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20.11.2024

Nonlinear receptive fields evoke redundant retinal coding of natural scenes

Authors Karamanlis D, Khani MH, Schreyer HM, Zapp SJ, Mietsch M, Gollisch T Journal Nature Citation Nature. 2024 Nov 20. Abstract The role of the vertebrate retina in early vision is generally described by the efficient coding hypothesis1,2, which predicts that the retina reduces the redundancy inherent in natural scenes3
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03.09.2024

Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina

Authors Krüppel S, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Zapp SJ, Mietsch M, Karamanlis D, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2024 Sep 3;20(9):e1012370. Abstract Spatially nonlinear stimulus integration by retinal ganglion cells lies at the heart of various computations performed by the retina.
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20.08.2024

Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

Authors Zapp SJ, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Krueppel S, Mietsch M, Protti DA, Karamanlis D, Gollisch T Journal eLife Citation eLife13:RP99945. Abstract A standard circuit motif in sensory systems is the pooling of sensory information from an upstream neuronal layer. A downstream neuron thereby collects signals
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09.03.2024

Convolutional neural network models of the primate retina reveal adaptation to natural stimulus statistics

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2024.03.06.583740. Abstract The diverse nature of visual environments demands that the retina, the first stage of the visual system, encodes a vast range of stimuli with various statistics. The retina adapts its computations to some
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