Fischer, André

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01.11.2025

lncRNA 3222401L13Rik/ENSG00000272070 modulates microglial inflammatory programs in association with PU.1

Authors Pradhan R, Sakib MS, Kaurani L, Krueger DM, Pena T, Burckhardt S, Schuetz AL, Kronenberg-Verstee D, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.10.31.685723. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to microglial aging and neurodegenerative disease
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24.10.2025

EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling

Authors Ulmke PA, Sakib MS, Nguyen DT, Muchamedin A, Sokpor G, Pham L, Xie Y, Abbas E, Castro Hernandez R, Narayanan R, Wincent J, Liedén A, Harris E, Joss S, Fischer A, Staiger JF, Nguyen HP, Tuoc T Journal Brain Citation Brain. 2025 Oct 24:awaf405. Abstract The evolutionarily conserved RNA
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19.08.2025

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain

Authors Kumar NH, Kluever V, Kaufmann SV, Bergmann C, Mousaei K, Tomas M, Marrero MC, Chopra A, Hirose M, Pallas M, Sanfeliu C, Ibrahim SM, Fischer A, Outeiro TF, Urlaub H, Tchumatchenko T, Lopez Otin C, Fornasiero EF Journal BioRxiv Citation bioRxiv 2025.08.14.669896 Abstract Brain aging is a major risk
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20.06.2025

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1

Authors Gather F, Rauleac T, Akol I, Arumugam G, Fullio CL, Müller T, Kleidonas D, Geiss-Friedlander R, Fischer A, Vlachos A, Backofen R, Vogel T Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jun 20;53(12):gkaf539. Abstract Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and
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12.06.2025

Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure

Authors Gisa V, Islam MR, Lbik D, Hofmann RM, Pena T, Krüger DM, Burkhardt S, Schütz AL, Sananbenesi F, Toischer K, Fischer A Journal Non-coding RNA Citation Noncoding RNA. 2025 Jun 12;11(3):45. Abstract Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet
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10.06.2025

Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

Authors Solomon P, Budde M, Kohshour MO, Adorja K, Heilbronner M, Navarro-Flores A, Papiol S, Reich-Erkelenz D, Schulte EC, Senner F, Vogl T, Kaurani L, Krüger DM, Sananbenesi F, Pena T, Burkhardt S, Schütz AL, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter AJ, Figge C, Juckel
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23.04.2025

Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders

Authors Solomon P, Kaurani L, Budde M, Guiné JB, Krüger DM, Riquin K, Pena T, Burkhardt S, Fourgeux C, Adorjan K, Heilbronner M, Kalman JL, Kohshour MO, Papiol S, Reich-Erkelenz D, Schaupp SK, Schulte EC, Senner F, Vogl T, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter
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11.04.2025

A role for astrocytic miR-129-5p in frontotemporal dementia

Authors Kaurani L, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Krüger DM, Pena T, Heutink P, Sananbenesi F, Fischer A Journal Translational Psychiatry Citation Transl Psychiatry. 2025 Apr 11;15(1):142. Abstract Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language
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29.01.2025

Engineered heart muscle allografts for heart repair in primates and humans

Authors Jebran AF, Seidler T, Tiburcy M, Daskalaki M, Kutschka I, Fujita B, Ensminger S, Bremmer F, Moussavi A, Yang H, Qin X, Mißbach S, Drummer C, Baraki H, Boretius S, Hasenauer C, Nette T, Kowallick J, Ritter CO, Lotz J, Didié M, Mietsch M, Meyer T, Kensah G, Krüger
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09.01.2025

LncRNA 3222401L13Rik Is Upregulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3

Authors Schröder S, Sakib MS, Krüger DM, Pena T, Burkhardt S, Schütz AL, Sananbenesi F, Fischer A Journal Noncoding RNA Citation Noncoding RNA. 2025 Jan 9;11(1):2. Abstract Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this
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