Research Alliance

Home >> Publications >> Research Alliance >> Seite 85
Feature image not available
09.07.2021

Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies

Authors Iqbal M, Maroofian R, Çavdarlı B, Riccardi F, Field M, Banka S, Bubshait DK, Li Y, Hertecant J, Baig SM, Dyment D, Efthymiou S, Abdullah U, Makhdoom EUH, Ali Z, Scherf de Almeida T, Molinari F, Mignon-Ravix C, Chabrol B, Antony J, Ades L, Pagnamenta AT, Jackson A, Douzgou
Learn More
Feature image not available
09.07.2021

isoSTED microscopy with water-immersion lenses and background reduction

Authors Siegmund R, Werner F, Jakobs S, Geisler C, Egner A Journal Biophysical Journal Citation Biophys J. 2021 Jul 8:S0006-3495(21)00556-7. Abstract Fluorescence microscopy is an excellent tool to gain knowledge on cellular structures and biochemical processes. Stimulated emission depletion (STED) microscopy provides a resolution in the range of a few
Learn More
Feature image not available
27.06.2021

Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils

Authors Joppe KDN, Tatenhorst L, Caldi Gomes L, Zhang S, Parvaz M, Carboni E, Roser AE, El DeBakey H, Bähr M, Vogel-Mikuš K, Ip CW, Becker S, Zweckstetter M, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2021 Jun 27. Abstract Regional iron accumulation and α-synuclein (α-syn) spreading pathology
Learn More
Feature image not available
25.06.2021

Loss-of-function variants in DNM1 cause a specific form of developmental and epileptic encephalopathy only in biallelic state

Authors Yigit G, Sheffer R, Daana M, Li Y, Kaygusuz E, Mor-Shakad H, Altmüller J, Nürnberg P, Douiev L, Kaulfuss S, Burfeind P, Wollnik B, Brockmann K Journal Journal of Medical Genetics Citation J Med Genet. 2021 Jun 25:jmedgenet-2021-107769. Abstract Background Developmental and epileptic encephalopathies (DEEs) represent a group of
Learn More
Feature image not available
17.06.2021

Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo

Authors Žumer K, Maier KC, Farnung L, Jaeger MG, Rus P, Winter G, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 Jun 17:S1097-2765(21)00441-X. In press. Abstract Transcription by RNA polymerase II (RNA Pol II) relies on the elongation factors PAF1 complex (PAF), RTF1, and SPT6. Here, we use rapid
Learn More
Feature image not available
17.06.2021

Concurrent axon and myelin destruction differentiates X-linked adrenoleukodystrophy from multiple sclerosis

Authors Bergner CG, Genc N, Hametner S, Franz J, van der Meer F, Mitkovski M, Weber MS, Stoltenburg-Didinger G, Kühl JS, Köhler W, Brück W, Gärtner J, Stadelmann-Nessler C Journal Glia Citation Glia, 2021, 1-16. Abstract Cerebral disease manifestation occurs in about two thirds of males with X-linked adrenoleukodystrophy (CALD)
Learn More
Feature image not available
16.06.2021

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

Authors Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2021 Jun 16;12(1):3672. Abstract Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC)
Learn More
Feature image not available
16.06.2021

Loss of BAF complex in developing cortex perturbs radial neuronal migration in a WNT signaling-dependent manner

Authors Sokpor G, Kerimoglu C, Nguyen H, Pham L, Rosenbusch J, Wagener R, Nguyen HP, Fischer A, Staiger JF, Tuoc T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 16 June 2021, 14: 687581. Abstract Radial neuronal migration is a key neurodevelopmental event indispensable for proper cortical laminar organization.
Learn More
Feature image not available
16.06.2021

Mapping Activity-Dependent Quasi-Stationary States of Mitochondrial Membranes with Graphene-Induced Energy Transfer Imaging

Authors Raja SO, Chizhik AI, Schmidt CF, Enderlein J, Ghosh A Journal Nano Letters Citation Nano Lett. 2021, 21, 8244−8249 Abstract Graphene-induced energy transfer (GIET) was recently introduced for sub-nanometric axial localization of fluorescent molecules. GIET relies on near-field energy transfer from an optically excited fluorophore to a single sheet
Learn More
Feature image not available
14.06.2021

Radiative Rate Modulation Reveals Near-Unity Quantum Yield of Graphene Quantum Dots

Authors Ghosh S, Oleksiievets N, Enderlein J, Chizhik AI Journal Advanced Optical Materials Citation Adv. Optical Mater. 2021, 2100314. Abstract A fundamental but difficult to assess photophysical property of quantum emitters is their fluorescence quantum yield. It describes how efficiently a fluorophore converts absorbed light into fluorescence. Conventional measurements of
Learn More
X
EN DE
X
X