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21.05.2021

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Authors Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E,
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18.05.2021

α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson’s Disease

Authors Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A Journal Movement Disorders Citation Mov Disord. 2021 May 18. Abstract Background: Extracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein
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14.05.2021

Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes

Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is
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10.05.2021

Physics-based reconstruction methods for magnetic resonance imaging

Authors Wang X, Tan Z, Scholand N, Roeloffs V, Uecker M Journal Philosophical Transactions Series A. Mathematical, physical, and engineering sciences Citation Philos Trans A Math Phys Eng Sci. 2021 Jun 28;379(2200):20200196. Abstract Conventional magnetic resonance imaging (MRI) is hampered by long scan times and only qualitative image contrasts that
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07.05.2021

Parental genome unification is highly erroneous in mammalian embryos

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early
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07.05.2021

Utility of red-light ultrafast optogenetic stimulation of the auditory pathway

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current
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06.05.2021

Efficient RNA polymerase II pause release requires U2 snRNP function

Authors Caizzi L, Monteiro-Martins S, Schwalb B, Lysakovskaia K, Schmitzova J, Sawicka A, Chen Y, Lidschreiber M, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 May 6;81(9):1920-1934.e9. Abstract Transcription by RNA polymerase II (Pol II) is coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly understood. Co-transcriptional splicing
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06.05.2021

Tejaas: reverse regression increases power for detecting trans-eQTLs

Authors Banerjee S, Simonetti FL, Detrois KE, Kaphle A, Mitra R, Nagial R, Söding J Journal Genome Biology Citation Genome Biol. 2021 May 6;22(1):142. Abstract Trans-acting expression quantitative trait loci (trans-eQTLs) account for ≥70% expression heritability and could therefore facilitate uncovering mechanisms underlying the origination of complex diseases. Identifying trans-eQTLs
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03.05.2021

Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane
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30.04.2021

Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo

Authors Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M Journal Molecular Therapy Citation Mol Ther. 2021 Apr 30;S1525-0016(21)00249-5.
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