Research Alliance

Authors Albariqi MMA, Baauw SMG, Fens SPJP, Versteeg S, Ryazanov S, Leonov A, Willemen HLDM, Stathonikos N, Seychell RM, El Saghir A, Gerritsen B, Khemtemourian L, Vassallo N, Giese A, Eijkelkamp N, Griesinger C, Höppener JWM Journal BioRxiv Citation bioRxiv 2024.08.27.609850. Abstract Cytotoxic aggregates of human islet amyloid polypeptide (hIAPP)

Authors Jain N, Gomkale R, Rehling P Journal Methods in Enzymology Citation Methods Enzymol. 2024;707:3-22. Abstract Mitochondria import the vast majority of proteins from the cytosol. Protein translocation machineries in outer and inner membranes facilitate precursor recognition and transport. Most mitochondrial proteins utilize N-terminal presequences as targeting signals that eventually

Authors Chaudhuri A, Eijsink LE, Simeth NA Journal Chemical Communications (Cambridge) Citation Chem Commun (Camb). 2024 Aug 22. Abstract The dynamic regulation of pH via an external stimulus is an attractive technique to gate chemical transformations. Applying photons of different energy, we preferentially address either a photoacid or a photobase

Authors Rudelt L, González Marx D, Spitzner FP, Cramer B, Zierenberg J, Priesemann V. Journal PLoS Computational Biology Citation PLoS Comput Biol. 2024 Aug 22;20(8):e1012355. Abstract A core challenge for the brain is to process information across various timescales. This could be achieved by a hierarchical organization of temporal processing

Authors Hundrieser S, Mordant G. Weitkamp CA, Munk A Journal Stochastic Processes and their Applications Citation Stochastic Processes and their Applications 178 (2024) 104462. Abstract Optimal transport (OT) based data analysis is often faced with the issue that the underlying cost function is (partially) unknown. This is addressed in this

Authors Wagner J, Carvajal AI, Bracher A, Beck F, Wan W, Bohn S, Körner R, Baumeister W, Fernandez-Busnadiego R, Hartl FU Journal Nature Citation Nature. 2024 Aug 21. Abstract Chaperonins are large barrel-shaped complexes that mediate ATP-dependent protein folding1-3. The bacterial chaperonin GroEL forms juxtaposed rings that bind unfolded protein

Authors Gligonov I, Enderlein J Journal Biophysical Journal Citation Biophys J. 2024 Aug 19:S0006-3495(24)00557-5. Abstract Zernike polynomials are a sequence of orthogonal polynomials that play a crucial role in optics and, in particular, modeling microscopy systems. Introduced by Frits Zernike in 1934, they are particularly useful in expressing wavefront aberrations

Authors Zapp SJ, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Krueppel S, Mietsch M, Protti DA, Karamanlis D, Gollisch T Journal eLife Citation eLife13:RP99945. Abstract A standard circuit motif in sensory systems is the pooling of sensory information from an upstream neuronal layer. A downstream neuron thereby collects signals

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Zimmermann WH, Schmidt CF Journal eLife Citation eLife 13:RP97321. Abstract Cardiac muscle function emerges from the coordinated contraction of sarcomeres in cardiomyocytes. Sarcomere dynamics are usually inferred from whole-cell or myofibril observations, assuming synchronized, uniform behavior. Here, we investigated how different

Authors Li F, Bahr JN, Bierth FA, Reshetniak S, Tetzlaff C, Fornasiero EF, Wichmann C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2024 Aug 12;7(11):e202402793. Abstract Synaptic proteins need to be replaced regularly, to maintain function and to prevent damage. It is unclear whether this process, known