Organized Protein Assemblies

Authors Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN Journal Nature Communications Citation Nat Commun 12, 4466 (2021). Abstract Macrolides and ketolides comprise a family of clinically important antibiotics that

Authors Bergner CG, Genc N, Hametner S, Franz J, van der Meer F, Mitkovski M, Weber MS, Stoltenburg-Didinger G, Kühl JS, Köhler W, Brück W, Gärtner J, Stadelmann-Nessler C Journal Glia Citation Glia, 2021, 1-16. Abstract Cerebral disease manifestation occurs in about two thirds of males with X-linked adrenoleukodystrophy (CALD)

Authors Rosado-Ramos R, Godinho-Pereira J, Marques D, Figueira I, Fleming Outeiro T, Menezes R, Nunes Dos Santos C Journal Molecules Citation Molecules. 2021 Jun 2;26(11):3353. Abstract Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson’s Disease (PD) is a neurodegenerative disorder known for its typical motor

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane

Authors Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M Journal Molecular Therapy Citation Mol Ther. 2021 Apr 30;S1525-0016(21)00249-5.

Authors Weish P, Lázaro DF, Palmares L, Santos PI, Stadelmann C, Höglinger GU, Rizzoli SO, Outeiro TF Journal bioRxiv Citation bioRxiv 2021.04.25.441304. Abstract Lewy bodies (LBs) and Lewy neurites are pathological hallmarks of Parkinson’s disease and other progressive neurodegenerative disorders known as Lewy body diseases (LBD). These proteinaceous deposits are immunopositive

Authors Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, McCoy RC, Xing J Journal Prenatal Diagnosis Citation Prenatal Diagnosis. 2021;1–11. Abstract The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than

Authors Jacinto S, Guerreiro P, de Oliveira RM, Cunha-Oliveira T, Santos MJ, Grazina M, Rego AC, Outeiro TF Journal Frontiers in Cellular Neuroscience Citation Front Cell Neurosci. 2021 Mar 17;15:641264. Abstract Mutations in the MPV17 gene are associated with hepatocerebral form of mitochondrial depletion syndrome. The mechanisms through which MPV17

Authors Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB Journal Frontiers in Aging Neuroscience Citation Front Aging Neurosci. 2021 Mar 22;13:635760. Abstract Tauopathies are neurodegenerative disorders with increasing incidence