Mitochondrial Gene Expression

Authors Rölleke U, Kumari P, Meyer R, Köster S Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2023 Oct 21;85:102263. Abstract Together with actin filaments and microtubules, intermediate filaments (IFs) constitute the eukaryotic cytoskeleton and each of the three filament types contributes very distinct mechanical properties to

Authors Jain N, Gomkale R, Bernhard O, Rehling P, Cruz-Zaragoza LD Journal EMBO Reports Citation EMBO Rep. 2023 Mar 20:e55760. Abstract Mitochondria play central roles in cellular energy production and metabolism. Most proteins required to carry out these functions are synthesized in the cytosol and imported into mitochondria. A growing

Authors Liu T, Stephan T, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2215799119. Abstract Capturing mitochondria’s intricate and dynamic

Authors Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S Journal Nature Methods Citation Nat Methods (2022). Abstract MINimal fluorescence photon FLUXes (MINFLUX) nanoscopy, providing photon-efficient fluorophore localizations, has brought about three-dimensional resolution at nanometer scales. However, by using an intrinsic on–off switching

Authors Bhatta A, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Jun 18:S0968-0004(22)00139-6. Abstract Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an evolutionarily distinct group of protein-only RNase Ps exists.

Authors Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, Łyszkiewicz M, Ziȩtara N, Liu Y, Frenz S, Sciuccati G, Partida-Gaytan A, Alizadeh Z, Rezaei N, Rehling P, Dennerlein S, Mann M, Klein C Journal Journal of Clinical Investigation Citation J Clin Invest. 2022 May 2;132(9):e153153. Abstract The relevance

Authors Bohnsack KE, Kleiber N, Lemus-Diaz N, Bohnsack MT Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Mar 29:S0968-0004(22)00063-9. Abstract Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m3C) has recently come to the fore through the identification of the

Authors Kolar MH, Nagy G, Kunkel J, Vaiana SM, Bock LV, Grubmüller H Journal Nucleic Acids Research Citation Nucleic Acids Res. 2022 Feb 28;50(4):2258-2269. Abstract The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact

Authors Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacińska A Journal Molecular Biology of the Cell Citation Mol Biol Cell. 2022 Jan 26:mbcE21030143. Abstract Assembly of the dimeric complex III (CIII2) in the mitochondrial inner

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial