Mitochondrial Gene Expression

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Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

Authors Liu T, Stephan T, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2215799119. Abstract Capturing mitochondria’s intricate and dynamic
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A quantitative fluorescence-based approach to study mitochondrial protein import

Authors Jain N, Gomkale R, Bernhard O, Rehling P, Cruz-Zaragoza LD Journal BioRxiv Citation bioRxiv 2022.10.10.511594. Abstract Mitochondria play central roles in cellular energy production and metabolism. Most of the proteins that are required to carry out these functions are synthesized in the cytosol and imported into mitochondria. A growing
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Authors Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S Journal Nature Methods Citation Nat Methods (2022). Abstract MINimal fluorescence photon FLUXes (MINFLUX) nanoscopy, providing photon-efficient fluorophore localizations, has brought about three-dimensional resolution at nanometer scales. However, by using an intrinsic on–off switching
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Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes

Authors Bhatta A, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Jun 18:S0968-0004(22)00139-6. Abstract Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an evolutionarily distinct group of protein-only RNase Ps exists.
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HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation

Authors Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, Łyszkiewicz M, Ziȩtara N, Liu Y, Frenz S, Sciuccati G, Partida-Gaytan A, Alizadeh Z, Rezaei N, Rehling P, Dennerlein S, Mann M, Klein C Journal Journal of Clinical Investigation Citation J Clin Invest. 2022 May 2;132(9):e153153. Abstract The relevance
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Roles and dynamics of 3-methylcytidine in cellular RNAs

Authors Bohnsack KE, Kleiber N, Lemus-Diaz N, Bohnsack MT Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Mar 29:S0968-0004(22)00063-9. Abstract Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m3C) has recently come to the fore through the identification of the
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Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel

Authors Kolar MH, Nagy G, Kunkel J, Vaiana SM, Bock LV, Grubmüller H Journal Nucleic Acids Research Citation Nucleic Acids Res. 2022 Feb 28;50(4):2258-2269. Abstract The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact
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Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III specific assembly factor in mitochondria

Authors Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacińska A Journal Molecular Biology of the Cell Citation Mol Biol Cell. 2022 Jan 26:mbcE21030143. Abstract Assembly of the dimeric complex III (CIII2) in the mitochondrial inner
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The RNA methyltransferase METTL8 installs m3C32 modifications in mitochondrial tRNAThr/Ser(UCN) to optimise tRNA structure and translation

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial
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Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

Authors Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P Journal Elife Citation Elife. 2021 Dec 31;10:e68213. Abstract Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system
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