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Authors Jablonski L, Harczos T, Wolf B, Hoch G, Dieter A, Hessler R, Ayub S, Ruther P, Moser T Journal bioRxiv Citation bioRxiv 2020.05.25.114868. Abstract In case of deafness, cochlear implants bypass dysfunctional or lost hair cells by direct electrical stimulation (eCIs) of the auditory nerve. However, spectral selectivity of

Authors Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P Journal Nature Citation Nature 584, 154–156 (2020). Abstract The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes1-3. Here

Authors Cavero I, Seimetz D, Koziel D, Zimmermann WH, Holzgrefe HH Journal Expert Opinion Drug Safety Citation Expert Opin Drug Saf. 2020 May;19(5):553-558. Abstract This report summarizes and discusses talks delivered at an educational course offered during the 2019 Annual Meeting of the Safety Pharmacology Society on advanced therapy medicinal

Authors Krüger JR, Keller-Findeisen J, Geisler C, Egner A Journal Biomedical Optics Express Citation Biomed. Opt. Express 11, 3139-3163 (2020). Abstract Stimulated emission depletion (STED) microscopy is a versatile imaging method with diffraction-unlimited resolution. Here, we present a novel STED microscopy variant that achieves either increased resolution at equal laser

Authors Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmuller J, Nurnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A, Pauli S Journal Human Genetics Citation Hum Genet. Online ahead of print Abstract We report truncating de novo variants in specific exons of

Authors Sograte-Idrissi S, Schlichthaerle T, Duque-Afonso CJ, Alevra M, Strauss S, Moser T, Jungmann R, Rizzoli SO, Opazo F Journal Nanoscale Citation Nanoscale. 2020 May 14;12(18):10226-10239. Abstract A standard procedure to study cellular elements is via immunostaining followed by optical imaging. This methodology typically requires target-specific primary antibodies (1.Abs), which

Authors Komorowski K, Schaeper J, Sztucki M, Sharpnack L, Brehm G, Köster S, Salditt T Journal Soft Matter Citation Soft Matter. 2020 May 6;16(17):4142-4154. Abstract We have used time-resolved small-angle X-ray scattering (SAXS) to study the adhesion of lipid vesicles in the electrostatic strong-coupling regime induced by divalent ions. The

Authors Jakobs S, Stephan T, Ilgen P, Brüser C Journal Annual Reviews of Biophysics Citation Annu Rev Biophys. 2020 May 6;49:289-308. Abstract Mitochondria are essential for eukaryotic life. These double-membrane organelles often form highly dynamic tubular networks interacting with many cellular structures. Their highly convoluted contiguous inner membrane compartmentalizes the

Authors Behr M, Ansari MA, Munk A , Holmes C Journal Proceedings of the National Academy of Sciences of the United States of America Citation PNAS May 5, 2020 117 (18) 9787-9792. Abstract Tree structures, showing hierarchical relationships and the latent structures between samples, are ubiquitous in genomic and biomedical

Authors Oleksiievets N, Thiele JC, Weber A, Gregor I, Nevskyi O, Isbaner S, Tsukanov R, Enderlein J Journal Journal of Physical Chemistry A Citation J Phys Chem A. 2020 Apr 30;124(17):3494-3500. Abstract Fluorescence lifetime imaging (FLIM) has become an important microscopy technique in bioimaging. The two most important of its applications are lifetime-multiplexing for imaging many different structures in