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30.01.2021

Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders

Authors Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I Journal Acta Neuropathologica Citation Acta Neuropathol. 2021 Jan 30. Abstract Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as Parkinson’s disease (PD), Parkinson’s
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29.01.2021

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

Authors Füllbrunn N, Li Z, Jorde L, Richter CP, Kurre R, Langemeyer L, Yu C, Meyer C, Enderlein J, Ungermann C, Piehler J, You C Journal Elife Citation Elife. 2021 Jan 29;10:e62501. Abstract Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic
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28.01.2021

Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci

Authors Kyryachenko S, Georges A, Yu M, Berrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras K, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N Journal Circulation Research Citation Circ Res. 2021 Jan 28. Abstract Rationale: Mitral valve prolapse (MVP) is a common valvopathy
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28.01.2021

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

Authors Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R Journal Molecular Cell Citation Mol Cell. 2021 Jan 28:S1097-2765(21)00016-2. Abstract In response to stress, human cells coordinately downregulate transcription and translation of housekeeping
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27.01.2021

Structures and implications of TBP-nucleosome complexes

Authors Wang H, Xiong L, Cramer P Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2108859118 Abstract The TATA box-binding protein (TBP) is highly conserved throughout eukaryotes and plays a central role in the
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27.01.2021

Multiscale quantile segmentation

Authors Vanegas LJ, Behr M, Munk A Journal Journal of the American Statistical Association Citation Journal of the American Statistical Association. 2021 Jan 27. Abstract We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does
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25.01.2021

Exploring early time points of vimentin assembly in flow by fluorescence fluctuation spectroscopy

Authors Perego E, Köster S Journal Lab on a Chip Citation Lab Chip. 2021 Jan 25. Abstract Despite the importance for cellular processes, the dynamics of molecular assembly, especially on fast time scales, is not yet fully understood. To this end, we present a multi-layer microfluidic device and combine it
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25.01.2021

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes

Authors Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JR, Sutanto H, Pacheu Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuβ G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener JW, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE Journal Circulation Research Citation
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21.01.2021

Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial.

Authors Backhaus SJ, Lange T, George EF, Hellenkamp K, Gertz RJ, Billing M, Wachter R, Steinmetz M, Kutty S, Raaz U, Lotz J, Friede T, Uecker M, Hasenfuß G, Seidler T, Schuster A Journal Circulation Citation Circulation. 2021 Jan 21. Abstract Background: Right heart catheterisation (RHC) using exercise-stress is the
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20.01.2021

Epigenetic gene expression links heart failure to memory impairment

Authors Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 Jan 20:e11900. Abstract In current clinical practice, care
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