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Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is

Authors Wang X, Tan Z, Scholand N, Roeloffs V, Uecker M Journal Philosophical Transactions Series A. Mathematical, physical, and engineering sciences Citation Philos Trans A Math Phys Eng Sci. 2021 Jun 28;379(2200):20200196. Abstract Conventional magnetic resonance imaging (MRI) is hampered by long scan times and only qualitative image contrasts that

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early

Authors Mojiri S, Isbaner S, Mühle S, Jang H, Bae AJ, Gregor I, Golami A, Enderlein J Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 3169-3180 (2021). Abstract High speed volumetric optical microscopy is an important tool for observing rapid processes in living cells or for real-time tracking of

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current

Authors Caizzi L, Monteiro-Martins S, Schwalb B, Lysakovskaia K, Schmitzova J, Sawicka A, Chen Y, Lidschreiber M, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 May 6;81(9):1920-1934.e9. Abstract Transcription by RNA polymerase II (Pol II) is coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly understood. Co-transcriptional splicing

Authors Banerjee S, Simonetti FL, Detrois KE, Kaphle A, Mitra R, Nagial R, Söding J Journal Genome Biology Citation Genome Biol. 2021 May 6;22(1):142. Abstract Trans-acting expression quantitative trait loci (trans-eQTLs) account for ≥70% expression heritability and could therefore facilitate uncovering mechanisms underlying the origination of complex diseases. Identifying trans-eQTLs

Authors Nies TG, Staudt T, Munk A Journal ArXiv Citation arXiv:2105.02073. Abstract For probability measures supported on countable spaces we derive limit distributions for empirical entropic optimal transport quantities. In particular, we prove that the corresponding plan converges weakly to a centered Gaussian process. Furthermore, its optimal value is shown

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane

Authors Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M Journal Molecular Therapy Citation Mol Ther. 2021 Apr 30;S1525-0016(21)00249-5.