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29.06.2024

Single-nucleus transcriptomics reveals adrenergic and STAT3 signaling in paradoxical low-flow low-gradient -specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment

Authors Xu X, Tan X, Cui B, Paul NB, Elkenani M, Beuthner BE, Li W, Mohamed BA, Schnelle M, Puls M, Zeisberg EM, Zeisberg M, Beißbarth T, Toischer K, Hasenfuß G Journal Cardiovascular Research Citation Cardiovasc Res. 2024 Jun 29:cvae137. Abstract No abstract available. DOI 10.1093/cvr/cvae137   Pubmed Link
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25.06.2024

Structural insights into the regulation of RyR1 by S100A1

Authors Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024
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24.06.2024

Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

Authors Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack
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22.06.2024

Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

Authors Outeiro TF, Brocardo PS, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2024 Jun 22. Abstract Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network.
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20.06.2024

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Authors Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Jun
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18.06.2024

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Authors Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt
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12.06.2024

X-ray phase-contrast tomography of cells manipulated with an optical stretcher

Authors Burchert JP, Frohn J, Rölleke U, Bruns H, Yu B, Gleber SC, Stange R, Busse M, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2024 Jul 1. Abstract X-rays can penetrate deeply into biological cells and thus allow for examination of their
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10.06.2024

Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

Authors Capel RA, Akerman E, Rog-Zielinska E, Winbo A, Aston D, Mu-u-min RBA, Read MJ, Bose SJ, Swietach P, Wang J, Corbett AD, Koschinski A, Montgomery JM, Falter F, Calamaio S, Melgari D, Prevostini R, Rivolta I, Ayagama T, Jenkin I, Simon JN, Fakuade FE, Pronto J, Sharma P, Song
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07.06.2024

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Rivera CP, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK Journal Science Advances Citation Sci Adv. 2024 Jun 7;10(23):eadn7191. Abstract Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a
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07.06.2024

Establishing synthetic ribbon-type active zones in a heterologous expression system

Authors Kapoor R, Schwenzer N, Dresbach T, Lehnart S, Moser T Journal eLife Citation eLife 13:RP98254. Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ) and might act as a super-scaffold organizing AZ
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