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22.07.2024

Transient Non-local Interactions Dominate the Dynamics of Measles Virus NTAIL

Authors Otteson L, Nagy G, Kunkel J, Kodis G, Zheng W, Bignon C, Longhi S, Grubmüller H, Vaiana AC, Vaiana SM Journal BioRxiv Citation bioRxiv 2024.07.22.604679. Abstract The RNA genome of measles virus is encapsidated by the nucleoprotein within a helical nucleocapsid that serves as template for both transcription and
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21.07.2024

Distributional limits of graph cuts on discretized grids

Authors Suchan L, Li H, Munk A Journal Arxiv Citation arXiv:2407.15297. Abstract Graph cuts are among the most prominent tools for clustering and classification analysis. While intensively studied from geometric and algorithmic perspectives, graph cut-based statistical inference still remains elusive to a certain extent. Distributional limits are fundamental in understanding
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19.07.2024

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Authors Talevi V, Melas K, Pehlivan G, Imtiaz MA, Krüger DM, Centeno TP, Aziz NA, Fischer A, Breteler MMB Journal Journal of Translational Medicine Citation J Transl Med. 2024 Jul 19;22(1):670. Abstract Background: As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several
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18.07.2024

FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites

Authors Antonicka H, Weraarpachai W, Vučković A, Hillen HS, Shoubridge EA Journal BioRxiv Citation bioRxiv 2024.07.18.603998. Abstract The regulation of mammalian mitochondrial gene expression is largely post-transcriptional and the first step in translating the 13 polypeptides encoded in mtDNA is endonucleolytic cleavage of the primary polycistronic transcripts. As the rRNAs
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16.07.2024

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy

Authors Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart
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13.07.2024

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L Journal Cell Reports Citation Cell Rep. 2024
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11.07.2024

A roadmap for ribosome assembly in human mitochondria

Authors Lavdovskaia E, Hanitsch E, Linden A, Pašen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MM, Urlaub H, Liepe J, Richter-Dennerlein R Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2024 Jul 11. Abstract Mitochondria contain dedicated ribosomes
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11.07.2024

Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile

Authors Oróstica KY, Mohr SB, Dehning J, Bauer S, Medina-Ortiz D, Iftekhar EN, Mujica K, Covarrubias PC, Ulloa S, Castillo AE, Daza-Sánchez A, Verdugo RA, Fernández J, Olivera-Nappa Á, Priesemann V, Contreras S Journal Scientific Reports Citation Sci Rep. 2024 Jul 11;14(1):16000. Abstract Genomic surveillance (GS) programmes were crucial in
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11.07.2024

Neurofilament Light Chain Serum Levels Mirror Age and Disability in Secondary Progressive Multiple Sclerosis: A Cross-Sectional Study

Authors Husseini L, Jung J, Boess N, Kruse N, Nessler S, Stadelmann C, Metz I, Haupts M, Weber MS Journal Neurology: Neuroimmunology & Neuroinflammation Citation Neurol Neuroimmunol Neuroinflamm. 2024 Sep;11(5):e200279. Abstract Objectives: To assess neurofilament light chain serum (sNfL) levels in patients with secondary progressive multiple sclerosis (SP-MS). Methods: Using
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08.07.2024

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response

Authors Hendrickson T, Giese A, Fiedler M, Perez W, Reyes-Sanchez E, Reyes-Lozano M, Wang S, Venegas-Zamora L, Provasek V, El-Essawi A, Breitenbach I, Fakuade F, Kutschka I, Schiattarella GG, Voigt N, Valderrábano M, Altamirano F Journal BioRxiv Citation bioRxiv 2024.07.08.602618. Abstract Background: The increasing prevalence of atrial fibrillation (AF) and
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