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23.12.2024

Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin

Authors Blob A, Ventzke D, Rölleke U, Nies G, Munk A, Schaedel L, Köster S   Journal Soft Matter   Citation Soft Matter, 2025, 21, 641-651.   Abstract The eukaryotic cytoskeleton is an intricate network of three types of mechanically distinct biopolymers — actin filaments, microtubules and intermediate filaments (IFs).
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19.12.2024

An Analytically Solvable Model of Firing Rate Heterogeneity in Balanced State Networks

Authors Schmidt A, Hiemeyer P, Wolf F Journal Arxiv Citation arXiv:2305.13420. Abstract Distributions of neuronal activity within cortical circuits are often found to display highly skewed shapes with many neurons emitting action potentials at low or vanishing rates, while some are active at high rates. Theoretical studies were able to
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19.12.2024

A Spatiotemporal Atlas of Mouse Gastrulation and Early Organogenesis to Explore Axial Patterning and Project In Vitro Models onto In Vivo Space

Authors Harland LTG, Lohoff T, Koulena N, Pierson N, Pape C, Ameen F, Griffiths J, Theeuwes B, Wilson NK, Kreshuk A, Reik W, Nichols J, Cai L, Marioni JC, Gottgens B, Ghazanfar S Journal BioRxiv Citation bioRxiv 2024.12.12.628063. Abstract At the onset of murine gastrulation, pluripotent epiblast cells migrate through
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18.12.2024

Proton Tunneling Allows a Proton-Coupled Electron Transfer Process in the Cancer Cell

Authors Zhang T, Ghosh A, Behringer-Pließ L, Chouhan L, Cunha AV, Havenith RWA, Butkevich E, Zhang L, Vázquez O, Debroye E, Enderlein J, Das S Journal Journal of the American Chemical Society Citation JACS Au 2024. Abstract Proton-coupled electron transfer (PCET) is a fundamental redox process and has clear advantages
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18.12.2024

A proteome-wide yeast degron collection for the dynamic study of protein function

Authors Valenti R, David Y, Edilbi D, Dubreuil B, Boshnakovska A, Asraf Y, Salame TM, Sass E, Rehling P, Schuldiner M Journal Journal of Cell Biology Citation J Cell Biol. 2025 Feb 3;224(2):e202409050. Abstract Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out.
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16.12.2024

Coupled infectious disease and behavior dynamics. A review of model assumptions

Authors Reitenbach A, Sartori F, Banisch S, Golovin A, Calero Valdez A, Kretzschmar M, Priesemann V, Mäs M Journal Reports on Progress in Physics Citation Rep. Prog. Phys. 88 016601. Abstract To comprehend the dynamics of infectious disease transmission, it is imperative to incorporate human protective behavior into models of
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16.12.2024

Wrapped up: advancements in volume electron microscopy and application in myelin research

Authors Schadt LC, Ruhwedel T, Pape C, Sasmita AO, Steyer AM, Möbius W Journal Methods in Microscopy Citation Methods in Microscopy. 2024. Abstract The three-dimensional visualization of cellular architecture by volume electron microscopy (vEM) has reignited interest in morphological descriptions of complex tissue. At the same time, the increasing availability
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11.12.2024

New insights into the molecular architecture of neurons by cryo-electron tomography

Authors Petrovic A, Do TT, Fernández-Busnadiego R Journal Current Opinion in Neurobiology Citation Curr Opin Neurobiol. 2024 Dec 11;90:102939. Abstract Cryo-electron tomography (cryo-ET) visualizes natively preserved cellular ultrastructure at molecular resolution. Recent developments in sample preparation workflows and image processing tools enable growing applications of cryo-ET in cellular neurobiology. As
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05.12.2024

Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways

Authors Hickey KL, Panov A, Whelan EM, Schäfer T, Mizrak A, Kopito RR, Baumeister W, Fernández-Busnadiego R, Harper JW Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2417390121. Abstract A hallmark of neurodegenerative diseases
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03.12.2024

What should a neuron aim for? Designing local objective functions based on information theory

Authors Schneider AC, Neuhaus V, Ehrlich DA, Makkeh A, Ecker AS, Priesemann V, Wibral M Journal Arxiv Citation arXiv:2412.02482. Abstract In modern deep neural networks, the learning dynamics of the individual neurons is often obscure, as the networks are trained via global optimization. Conversely, biological systems build on self-organized, local
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