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17.09.2024

Multiplex Microscopy Assay for Assessment of Therapeutic and Serum Antibodies against Emerging Pathogens

Authors Sartingen N, Stürmer V, Kaltenböck M, Müller TG, Schnitzler P, Kreshuk A, Kräusslich HG, Merle U, Mücksch F, Müller B, Pape C, Laketa V Journal Viruses Citation Viruses 2024, 16(9), 1473. Abstract The emergence of novel pathogens, exemplified recently by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights
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17.09.2024

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

Authors Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, Brose N, Taschenberger H, Krueger-Burg D Journal Communications Biology Citation Commun Biol. 2024 Sep 17;7(1):1157. Abstract Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all
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13.09.2024

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

Authors Naas J, Nies G, Li H, Stoldt S, Schmitzer B, Jakobs S, Munk A Journal Communications Biology Citation Commun Biol 7, 1139 (2024). Abstract With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate
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12.09.2024

The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathy

Authors Chopra A, Xylaki M, Yin F, Castro-Hernández R, Merghani M, Grande V, Mollenhauer B, Fischer A, Outeiro TF Journal BioRxiv Citation bioRxiv 2024.09.12.612649. Abstract N6-methyladenosine (m6A) is the most abundant and conserved transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A in the development of
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10.09.2024

KRASG12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

Authors Tapia Contreras C, Falke JD, Seifert DM, Schneider C, Krauß L, Fang X, Müller D, Demirdizen E, Spitzner M, De Oliveira T, Schneeweis C, Gaedcke J, Kaulfuß S, Mirzakhani K, Wollnik B, Conrads K, Beißbarth T, Salinas G, Hügel J, Beyer N, Rheinländer S, Sax U, Wirth M, Conradi
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09.09.2024

Rational approximation of golden angles: Accelerated reconstructions for radial MRI

Authors Scholand N, Schaten P, Graf C, Mackner D, Holme HCM, Blumenthal M, Mao A, Assländer J, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2024 Sep 9. Abstract Purpose: To develop a generic radial sampling scheme that combines the advantages of golden ratio sampling with simplicity
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03.09.2024

Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry

Authors Welp LM, Sachsenberg T, Wulf A, Chernev A, Horokhovskyi Y, Neumann P, Pašen M, Siraj A, Raabe M, Johannsson S, Schmitzova J, Netz E, Pfeuffer J, He Y, Fritzemeier K, Delanghe B, Viner R, Vos SM, Cramer P, Ficner R, Liepe J, Kohlbacher O, Urlaub H Journal BioRxiv Citation
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03.09.2024

Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina

Authors Krüppel S, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Zapp SJ, Mietsch M, Karamanlis D, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2024 Sep 3;20(9):e1012370. Abstract Spatially nonlinear stimulus integration by retinal ganglion cells lies at the heart of various computations performed by the retina.
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02.09.2024

Scattering-Based Super-Resolution Optical Fluctuation Imaging

Authors Yudovich S, Posnjak G, Shani L, Teblum E, Liedl T, Enderlein J, Weiss S Journal BioRxiv Citation bioRxiv 2024.09.02.610873. Abstract Super-resolution optical imaging has become a prominent tool in life and material sciences, allowing one to decipher structures at increasingly greater spatial detail. Among the utilized techniques in this
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01.09.2024

Optimistic Search: Change Point Estimation for Large-scale Data via Adaptive Logarithmic Queries

Authors Kovacs S, Li H, Haubner L, Munk A, Buhlmann P Journal Journal of Machine Learning Research Citation J Mach Learn Res 25(297):1−64, 2024. Abstract Change point estimation is often formulated as a search for the maximum of a gain function describing improved fits when segmenting the data. Searching one
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