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16.12.2024

Wrapped up: advancements in volume electron microscopy and application in myelin research

Authors Schadt LC, Ruhwedel T, Pape C, Sasmita AO, Steyer AM, Möbius W Journal Methods in Microscopy Citation Methods in Microscopy. 2024. Abstract The three-dimensional visualization of cellular architecture by volume electron microscopy (vEM) has reignited interest in morphological descriptions of complex tissue. At the same time, the increasing availability
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11.12.2024

New insights into the molecular architecture of neurons by cryo-electron tomography

Authors Petrovic A, Do TT, Fernández-Busnadiego R Journal Current Opinion in Neurobiology Citation Curr Opin Neurobiol. 2024 Dec 11;90:102939. Abstract Cryo-electron tomography (cryo-ET) visualizes natively preserved cellular ultrastructure at molecular resolution. Recent developments in sample preparation workflows and image processing tools enable growing applications of cryo-ET in cellular neurobiology. As
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05.12.2024

Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways

Authors Hickey KL, Panov A, Whelan EM, Schäfer T, Mizrak A, Kopito RR, Baumeister W, Fernández-Busnadiego R, Harper JW Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2417390121. Abstract A hallmark of neurodegenerative diseases
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03.12.2024

What should a neuron aim for? Designing local objective functions based on information theory

Authors Schneider AC, Neuhaus V, Ehrlich DA, Makkeh A, Ecker AS, Priesemann V, Wibral M Journal Arxiv Citation arXiv:2412.02482. Abstract In modern deep neural networks, the learning dynamics of the individual neurons is often obscure, as the networks are trained via global optimization. Conversely, biological systems build on self-organized, local
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02.12.2024

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Authors Muth S, Moschref F, Freckmann L, Mutschall S, Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C Journal BioRxiv Citation bioRxiv 2024.12.02.626387. Abstract Electron
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30.11.2024

Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy

Authors Chen T, Karedla N, Enderlein J Journal Communications Biology Citation Commun Biol. 2024 Nov 30;7(1):1596. Abstract Epithelial cadherin (E-cad) mediated cell-cell junctions play a crucial role in the establishment and maintenance of tissues and organs. In this study, we employed metal-induced energy transfer imaging and spectroscopy to investigate variations
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22.11.2024

Societal self-regulation induces complex infection dynamics and chaos

Authors Wagner J, Bauer S, Contreras S, Fleddermann L, Parlitz U, Priesemann V Journal Physical Review Research Citation Phys Rev Research. 2024. accepted paper. Abstract Classically, endemic infectious diseases are expected to display relatively stable, predictable infection dynamics. Accordingly, basic disease models such as the SIRS model display stable endemic
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20.11.2024

Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes

Authors Cheng S, Schuh M Journal Nature Communications Citation Nat Commun. 2024 Nov 20;15(1):10044. Abstract In mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation
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20.11.2024

Nonlinear receptive fields evoke redundant retinal coding of natural scenes

Authors Karamanlis D, Khani MH, Schreyer HM, Zapp SJ, Mietsch M, Gollisch T Journal Nature Citation Nature. 2024 Nov 20. Abstract The role of the vertebrate retina in early vision is generally described by the efficient coding hypothesis1,2, which predicts that the retina reduces the redundancy inherent in natural scenes3
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15.11.2024

Trials and tribulations of cell therapy for heart failure: an update on ongoing trials

Authors Zhang JJ, Pogwizd SM, Fukuda K, Zimmermann WH, Fan C, Hare JM, Bolli R, Menasché P Journal Nature Reviews. Cardiology Citation Nat Rev Cardiol. 2024 Nov 15. Abstract Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with
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