2026

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23.07.2026

Focal astrocyte loss reveals nuclear translocation during lesion repopulation

Authors Herwerth M, Wyss MT, Schmid NB, Lasne A, Condrau J, Ravotto L, Mateos Melero JM, Kaech A, Bredell G, Thomas C, Kim R, Kukanja P, Korobeynyk VL, Stadelmann C, Misgeld T, Bennett JL, Jessberger S, Saab AS, Liddelow SA, Weber B Journal Nature Neuroscience Citation Nat Neurosci. 2026 Jul
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17.07.2026

Structure and dynamics of the Nipah virus RNA-dependent RNA polymerase

Authors Sala FA, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2026 Jul 17:S0968-0004(26)00203-3. Abstract Nipah virus (NiV) is a highly pathogenic, nonsegmented, negative-sense RNA virus (nsNSV) from the Mononegavirales order that causes frequent outbreaks, with no approved treatment available. Replication and transcription of its genome are
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14.07.2026

RBM20 variants disrupt Ca2+ handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models

Authors Rebs S, Sedaghat-Hamedani F, Kayvanpour E, Eberl H, Berečić B, Dudek J, Wagensohner N, Seedorf A, Unsöld JK, Hübscher D, Reich C, Klein T, Doose S, Nikolaev VO, Buchwald T, Wagdi A, Kohlhaas M, Dybkova N, Morais Costa P, Guan K, Hasenfuss G, Rog-Zielinska EA, Sossalla S, Sauer M,
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09.07.2026

The lncRNA Gm16685/MITA1 modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signaling

Authors Fuchs U, Schroeder S, Pena T, Krueger DM, Burkhardt S, Schuetz AL, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736437. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of cellular identity and disease associated gene expression programs, yet their role in astrocyte reactivity remains poorly understood.
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07.07.2026

Inferring Cooperativity From Pooled Measurements

Authors Requardt R, Li H Journal Arxiv Citation arXiv:2607.03088 Abstract In many modern experiments, latent interactions drive multicomponent stochastic systems, yet the data are available only as pooled measurements that obscure these dependencies. Whether such interactions can be identified and inferred from aggregate signals remains largely unexplored. Motivated by multi-channel
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03.07.2026

Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes

Authors Fuchs U, Schroeder S, Pena t, Krueger DM, Burkhardt S, Schuetz AL, Hempel N, Gisa V, Taghavi T, Cortes J, Gertig M, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736275. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their
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01.07.2026

Artificial Intelligence for Discovery in Life Sciences

Authors Chanda S, Rizzoli SO, Shaib AH Journal Bioconjugate Chemistry Citation Bioconjug Chem. 2026 Jul 1. Abstract Artificial intelligence is becoming a transformative tool in life sciences, not just by improving the results of existing technologies but also by introducing fundamental new ways of discovery. Initially applied to denoising, segmentation,
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26.06.2026

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease

Authors da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez D, Klein R, Giese A, Griesinger C, Dudanova I Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2026 Jun 26. Abstract Huntington’s disease (HD) is a hereditary movement disorder caused by a CAG repeat expansion in
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24.06.2026

Molecular mechanisms of E-Syt-mediated stress resistance

Authors Benitez-Fuente F, Collado J, Morello-Lopez J, Pagano-Marquez R, Ruiz-Lopez N, Keller J, Botella MA, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2026.06.23.733366. Abstract Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma membrane (PM) enable direct intermembrane exchange of signals and metabolites. The Extended Synaptotagmins (E-Syts) are
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22.06.2026

Distributed representations of chemosensory valence in a naive vertebrate brain

Authors Jenkins B, Frank T Journal BioRxiv Citation bioRxiv 2026.06.17.732810. Abstract Chemical cues guide essential behaviors by signaling food, danger, and social information. A major dimension of chemosensory processing is valence, which biases animals toward approach or avoidance, yet its brain-wide organization in vertebrates remains unclear. Here, we used larval
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