2026

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27.08.2026

Signatures of Hebbian plasticity in the nanoscale morphodynamics of cortical spines

Authors Soltanipour M, Nagel A, Willig KI, Wolf F Journal BioRxiv Citation bioRxiv 2026.08.27.747454. Abstract The size, shape, and nanoscale organization of synaptic spines are predictive of physiological synaptic strength and thus key to connectome-based neural circuit models. In the intact brain, spine size and shape undergo continuous morphological remodeling.
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26.08.2026

Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy

Authors Habenstein F, Jensen N, Stumpf D, Chizhik AI, Leutenegger M, Chang J, Fognini A, Qin-Dregely J, Zadeh IE, Kirck LL, Enderlein J, Inamdar K, Hell SW, Jakobs S Journal Proceedings of the National Academy of Sciences of the USA Citation Proc Natl Acad Sci U S A. 2026 Sep;123(35):e2533451123.
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26.08.2026

Molecular basis for a Ca2+ binding hierarchy in the EF-hand motifs of CaBP2

Authors Motosugi R, Walinda E, Kim T, Mateias AL, Pallinger T, Prajapati S, Morimoto D, Kim M, Rankovic V, Griesinger C, Tittmann K, Pangrsic T, Sakata E Journal Journal of Biological Chemistry Citation J Biol Chem. 2026 Aug 26:113492. Abstract Calcium binding protein 2 (CaBP2), a member of the calmodulin
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26.08.2026

Systematic Review and Transcriptomic Meta-analysis of Environmental Enrichment Reveal Core Molecular Programs of Brain Plasticity

Authors Kurowska M, Miozzo F, Schroeder R, Machnicka MA, Pérez-González R, Merienne K, Fischer A, Barco A, Boutillier AL, Wilczyński B Journal Molecular Neurobiology Citation Mol Neurobiol. 2026 Aug 26;63(1):857. Abstract Environmental enrichment (EE) paradigms in rodents have long demonstrated that enhanced sensory, cognitive, social, and motor stimulation positively impacts
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26.08.2026

In silico framework for benchmarking optogenetic hearing restoration

Authors Khurana L, Nejedly P, Zhang Y, Jagger DJ, Nogueira W, Moser T, Jablonski L Journal Journal of Neural Engineering Citation J Neural Eng. 2026 Aug 26. Abstract Objective: Cochlear implants (CI) partially restore hearing in profoundly hearing-impaired or deaf individuals by electrically stimulating the auditory nerve. A primary bottleneck
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22.08.2026

Distinct mitochondrial DNA single-nucleotide variant signatures in TOP3A-deficient cardiomyocytes

Authors Gaubert M, Alachram H, Gönenç II, Domínguez I, Argyriou C, Schmidt J, Kaulfuß S, Pavez-Giani M, Schott CT, Munk A, Zibat A, Cyganek L, Yigit G, Wollnik B Journal BioRxiv Citation bioRxiv 2026.08.18.745450. Abstract The human heart has a continuous and exceptionally high demand for energy, which is met
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18.08.2026

Dielectric Interfaces Reshape Dynamic Single-Molecule Optical Fingerprints in Nanoscopic Polymer Films

Authors Marx D, Malsbenden D, Gligonov I, Wöll D, Enderlein J, Nevskyi O Journal ChemRxiv Citation ChemRxiv. 18 August 2026. Abstract Fluorescence lifetimes near dielectric interfaces depend on molecular dipole orientation, but this relationship becomes more complex when emitters are confined within finite nanoscopic films. Here, we combine radially polarized
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14.08.2026

Adaptation of OXPHOS biogenesis to cellular requirements

Authors Dennerlein S, Rehling P Journal Protein Science Citation Protein Sci. 2026 Sep;35(9):e70763. Abstract Metabolic cues regulate the formation of the mitochondrial OXPHOS machinery. These regulatory processes are tightly linked to mitochondrial translation, proteolytic degradation of unassembled subunits, and the formation of supercomplexes, creating checkpoints at which nutrient availability, oxygen
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11.08.2026

Optimizing infectious disease mitigation under dynamic conditions

Authors Müller L, Sartori F, Dehning J, Eggl MF, Priesemann V Journal Proceedings of the National Academy of Sciences of the USA Citation Proc Natl Acad Sci U S A. 2026 Aug 11;123(32):e2527395123. Abstract Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but
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11.08.2026

ONE microscopy

Authors Shaib AH, Alawieh MM, Rizzoli SO Journal Nature Protocols Citation Nat Protoc. 2026 Aug 11. Abstract The introduction of expansion microscopy (ExM), a decade ago, marked a shift in super-resolution imaging, by physically separating fluorophores to bypass the diffraction limit. Numerous ExM developments have extended the method’s reach since,
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