2024

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09.02.2024

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction

Authors Gotthardt M, Lehnart SE   Journal Cardiovascular Research   Citation Cardiovasc Res. 2024 Feb 9:cvae030.   Abstract No abstract available.   DOI 10.1093/cvr/cvae030   Pubmed Link
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08.02.2024

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

Authors Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S   Journal Nature Structural & Molecular Biology   Citation Nat Struct Mol Biol (2024).   Abstract Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system
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08.02.2024

Model-Based Reconstruction for Joint Estimation of T1, R∗2 and B0 Field Maps Using Single-Shot Inversion-Recovery Multi-Echo Radial FLASH

Authors Wang X, Scholand N, Tan Z, Mackner D, Telezki V, Blumenthal M, Schaten P, Uecker M Journal Arxiv Citation arXiv:2402.05366. Abstract Purpose: To develop a model-based nonlinear reconstruction for simultaneous water-specific T1, R∗2, B0 field and/or fat fraction (FF) mapping using single-shot inversion-recovery (IR) multi-echo radial FLASH. Methods: The
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07.02.2024

Characterizing ATP processing by the AAA+ protein p97 at the atomic level

Authors Shein M, Hitzenberger M, Cheng T, Rout S, Leitl K, Sato Y, Zacharias M, Sakata E, Schuetz A Journal Nature Chemistry Citation Nat. Chem. (2024). Abstract The human enzyme p97 regulates various cellular pathways by unfolding hundreds of protein substrates in an ATP-dependent manner, making it an essential component
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01.02.2024

A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria

Authors Höglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE Journal The Lancet. Neurology Citation Lancet Neurol. 2024 Feb;23(2):191-204. Erratum in: Lancet Neurol. 2024 Mar;23(3):e7. Abstract With the hope that disease-modifying treatments could target the molecular basis of Parkinson’s disease, even
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01.02.2024

Limit distributions and sensitivity analysis for empirical entropic optimal transport on countable spaces

Authors Hundrieser S, Klatt M, Munk A Journal The Annals of Applied Probability Citation Ann. Appl. Probab. 34(1B): 1403-1468. Abstract For probability measures on countable spaces we derive distributional limits for empirical entropic optimal transport quantities. More precisely, we show that the empirical optimal transport plan weakly converges to a
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28.01.2024

Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line

Authors Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2024 Jan 28;75:103317. Abstract Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal
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26.01.2024

High throughput methods for cardiac cellular electrophysiology studies: The road to personalized medicine

Authors Seibertz F, Voigt N Journal American Journal of Physiology: Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jan 26. Abstract Personalized medicine refers to the tailored application of medical treatment at an individual level, taking into account the specific genotype or phenotype of each patient
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25.01.2024

Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations

Authors Alfken J, Neuhaus C, Major A, Taskina A, Hoffmann C, Ganzella M, Petrovic A, Zwicker D, Fernández-Busnadiego R, Jahn R, Milovanovic D, Salditt T Journal European Physical Journey. E, Soft Matter Citation Eur Phys J E Soft Matter. 2024 Jan 25;47(1):8. Abstract We study the formation of vesicle condensates
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24.01.2024

Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions

Authors Bloothooft M, Verbruggen B, Seibertz F, van der Heyden MAG, Voigt N, de Boer TP Journal Frontiers in Physiology Citation Front Physiol. 2024 Jan 24;15:1298340. Abstract Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately
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