2023

Authors Bock LV, Grubmüller H Journal Nature Communications Citation Nat Commun. 2022 Mar 31;13(1):1709. Abstract Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what

Authors Hauke L, Isbaner S, Ghosh A, Guido I, Turco L, Chizhik AI, Gregor I, Karedla N, Rehfeldt F, Enderlein J Journal ACS Nano Citation ACS Nano. 2023 Mar 30. Abstract Metal-induced energy transfer (MIET) imaging is an easy-to-implement super-resolution modality that achieves nanometer resolution along the optical axis of

Authors Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF Journal Chemistry – A European Journal Citation Chem. Eur. J.2023, e202300649. Abstract Alpha-Synuclein (α-Synuclein) is a 140 amino acid protein implicated in neurodegenerative disorders known as synucleino-pathies, where it accumulates in proteinaceous inclusions in the brain. The normal physiological function of

Authors Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S   Journal Nature Structural and Molecular Biology   Citation Nat Struct Mol Biol. 2023 Mar 27.   Abstract Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the

Authors Zerche M, Wrobel C, Kusch K, Moser T, Mager T Journal Molecular Therapy: Methods and Clinical Development Citation Molecular Therapy: Methods & Clinical Development Vol. 29 June 2023. Abstract Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically

Authors Jain N, Gomkale R, Bernhard O, Rehling P, Cruz-Zaragoza LD Journal EMBO Reports Citation EMBO Rep. 2023 Mar 20:e55760. Abstract Mitochondria play central roles in cellular energy production and metabolism. Most proteins required to carry out these functions are synthesized in the cytosol and imported into mitochondria. A growing

Authors Witte S, Boshnakovska A, Özdemir M, Chowdhury A, Rehling P, Aich A   Journal Biology Open   Citation Biol Open. 2023 Mar 15;12(3):bio059844.   Abstract Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild

Authors Luo G, Blumenthal M, Heide M, Uecker M   Journal Magnetic Resonance in Medicine   Citation Magn Reson Med. 2023 Mar 13.   Abstract Purpose: We introduce a framework that enables efficient sampling from learned probability distributions for MRI reconstruction. Method: Samples are drawn from the posterior distribution given

Authors Dorn AE, de Bruyn E, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P   Journal BioRxiv   Citation bioRxiv 2023.03.10.531864.   Abstract Serine 129 and, to a lesser extent, serine 87 can appear phosphorylated in the intrinsically disordered protein human α-synuclein (AS), a key player in Parkinson’s

Authors Ghosh S, Ross U, Chizhik AM, Kuo Y, Jeong BG, Bae WK, Park K, Li J, Oron D, Weiss S, Enderlein J, Chizhik AI Journal The Journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2023 Mar 9:2702-2707. Abstract One of the key phenomena that determine the fluorescence