Latest Publications

Authors Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2020, 21(16), 5724. Abstract Neurodevelopmental and late-onset neurodegenerative disorders present as separateentities that are clinically and neuropathologically quite distinct. However, recent evidence hashighlighted surprising commonalities

Authors Salfer M, Collado JF, Baumeister W, Fernández-Busnadiego R, Martínez-Sánchez A Journal PLoS Computational Biology Citation PLoS Comput Biol. 2020 Aug 10;16(8):e1007962. Online ahead of print. Abstract Curvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a

Authors Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF Journal Brain Pathology Citation Brain Pathol. 2020;10.1111/bpa.12890. Abstract Loss of function mutations within the vesicular trafficking protein Ras analogy in brain 39B (RAB39B) are associated with rare X‐linked Parkinson’s disease (PD). Physiologically, RAB39B is localized

Authors Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF Journal Scientific Reports Citation Sci Rep 10, 12827 (2020). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect

Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as

Authors Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T Journal Science Translational Medicine Citation Sci. Transl. Med. 12, eabb8086 (2020). Abstract Cochlear implants provide the brain

Authors Bonnin EA, Rizzoli SO Journal Frontiers in Behavioral Neuroscience Citation Front Behav Neurosci. 2020 Jul 20;14:124. Abstract The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically

Authors Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli S Journal EMBO Journal Citation EMBO J. 2020 Jul 6;e104596. Abstract Many proteins involved in synaptic transmission are well known, and their features, as their abundance or spatial distribution, have been analyzed

Authors Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L Journal Circulation Citation Circulation. 2020;10.1161/CIRCULATIONAHA.119.044794.

Authors Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020;gkaa549. published online ahead of print, 2020 Jul 1. Abstract MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression and their dysfunction is often associated with cancer. Alongside the canonical miRNA