Latest Publications

Authors Reinert MC, Pacheu-Grau D, Catarino CB, Klopstock T, Ohlenbusch A, Schittkowski M, Wilichowski E, Rehling P, Brockmann K Journal Orphanet Journal of Rare Diseases Citation Orphanet J Rare Dis. 2021 Feb 4;16(1):64. Abstract Background: Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder and characterized by acute

Authors Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S. Journal Nature Communications Citation Nat Commun. 2021 Feb 4;12(1):782. Abstract The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins,

Authors Dankovich TM, Rizzoli SO Journal iScience Citation iScience. 2021 Feb 3;24(3):102134. Abstract Optical super-resolution microscopy (SRM) has enabled biologists to visualize cellular structures with near-molecular resolution, giving unprecedented access to details about the amounts, sizes and spatial distributions of macromolecules in the cell. Precisely quantifying these molecular details requires

Authors Sakib MS, Sokpor G, Nguyen HP, Fischer A, Tuoc T Journal Star Protocols Citation STAR Protoc. 2021 Feb 2;2(1):100318. Abstract Cell sorting can be used to purify cell populations for cell type-specific molecular probing. Fluorescence-activated cell sorting (FACS) coupled with high-throughput sequencing affords molecular signature identification for specific cell

Authors Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I Journal Acta Neuropathologica Citation Acta Neuropathol. 2021 Jan 30. Abstract Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as Parkinson’s disease (PD), Parkinson’s

Authors Füllbrunn N, Li Z, Jorde L, Richter CP, Kurre R, Langemeyer L, Yu C, Meyer C, Enderlein J, Ungermann C, Piehler J, You C Journal Elife Citation Elife. 2021 Jan 29;10:e62501. Abstract Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic

Authors Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R Journal Molecular Cell Citation Mol Cell. 2021 Jan 28:S1097-2765(21)00016-2. Abstract In response to stress, human cells coordinately downregulate transcription and translation of housekeeping

Authors Vanegas LJ, Behr M, Munk A Journal Journal of the American Statistical Association Citation Journal of the American Statistical Association. 2021 Jan 27. Abstract We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does

Authors Perego E, Köster S Journal Lab on a Chip Citation Lab Chip. 2021 Jan 25. Abstract Despite the importance for cellular processes, the dynamics of molecular assembly, especially on fast time scales, is not yet fully understood. To this end, we present a multi-layer microfluidic device and combine it

Authors Backhaus SJ, Lange T, George EF, Hellenkamp K, Gertz RJ, Billing M, Wachter R, Steinmetz M, Kutty S, Raaz U, Lotz J, Friede T, Uecker M, Hasenfuß G, Seidler T, Schuster A Journal Circulation Citation Circulation. 2021 Jan 21. Abstract Background: Right heart catheterisation (RHC) using exercise-stress is the