Latest Publications

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F   Journal ArXiv   Citation arXiv:2304.04279.   Abstract The dynamics of living systems often serves the purpose of reaching functionally important target states. We previously proposed a theory to analyze stochastic biological dynamics evolving towards target states in reverse

Authors Dervişoğlu R, Antonschmidt L, Nimerovsky E, Sant V, Kim M, Ryazanov S, Leonov A, Carlos Fuentes-Monteverde J, Wegstroth M, Giller K, Mathies G, Giese A, Becker S, Griesinger C, Andreas LB Journal Methods Citation Methods. 2023 Apr 8:S1046-2023(23)00056-7. Abstract Small molecules that bind to oligomeric protein species such as

Authors Lenner N, Eule S, Großhans J, Wolf F Journal Arxiv Citation arXiv:2304.03226. Abstract Mesoscopic bio-systems typically evolve towards functionally important target states, such as cell-cycle checkpoints or decision boundaries for the release of specific behaviors. For the data-driven inference of the underlying directional out-of-equilibrium dynamics, we here develop a

Authors Chatterjee M, Özdemir S, Kunadt M, Koel-Simmelink M, Boiten W, Piepkorn L, Pham TV, Chiasserini D, Piersma SR, Knol JC, Möbius W, Mollenhauer B, van der Flier WM, Jimenez CR, Teunissen CE, Jahn O, Schneider A Journal Alzheimer’s & Dementia: The Journal of the Alzheimers Association Citation Alzheimers Dement.

Authors Seibertz F, Sutanto H, Dülk R, Pronto JRD, Springer R, Rapedius M, Liutkute A, Ritter M, Jung P, Stelzer L, Hüsgen LM, Klopp M, Rubio T, Fakuade FE, Mason FE, Hartmann N, Pabel S, Streckfuss-Bömeke K, Cyganek L, Sossalla S, Heijman J, Voigt N Journal Basic Research in Cardiology

Authors Schilbach S, Wang H, Dienemann C, Cramer P Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2220542120. Abstract For transcription initiation, RNA polymerase II (Pol II) forms a preinitiation complex (PIC) that associates with the general coactivator Mediator. Whereas

Authors Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D’Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M,

Authors Bock LV, Grubmüller H Journal Nature Communications Citation Nat Commun. 2022 Mar 31;13(1):1709. Abstract Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what

Authors Hauke L, Isbaner S, Ghosh A, Guido I, Turco L, Chizhik AI, Gregor I, Karedla N, Rehfeldt F, Enderlein J Journal ACS Nano Citation ACS Nano. 2023 Mar 30. Abstract Metal-induced energy transfer (MIET) imaging is an easy-to-implement super-resolution modality that achieves nanometer resolution along the optical axis of

Authors Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF Journal Chemistry – A European Journal Citation Chem. Eur. J.2023, e202300649. Abstract Alpha-Synuclein (α-Synuclein) is a 140 amino acid protein implicated in neurodegenerative disorders known as synucleino-pathies, where it accumulates in proteinaceous inclusions in the brain. The normal physiological function of